ZIKA virus entry mechanisms in human cells

被引:90
作者
Agrelli, Almerinda [1 ]
de Moura, Ronald Rodrigues [2 ]
Crovella, Sergio [1 ,2 ]
Cavalcanti Brandao, Lucas Andre [1 ,3 ]
机构
[1] Fed Univ Pernambuco UFPE, LIKA, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil
[2] Fed Univ Pernambuco UFPE, Dept Genet, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil
[3] Fed Univ Pernambuco UFPE, Dept Pathol, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil
关键词
ZIKV; C-type lectin receptors; Apoptotic mimicry; ZIKV protein prM; ZIKV protein E; HUMAN DENDRITIC CELLS; C-TYPE LECTINS; DENGUE-VIRUS; DC-SIGN; JAPANESE ENCEPHALITIS; INHIBITS ZIKA; PRODUCTIVE INFECTION; CEREBRAL ORGANOIDS; HEPARAN-SULFATE; LINKED GLYCANS;
D O I
10.1016/j.meegid.2019.01.018
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Zika virus (ZIKV) is an enveloped, mosquito-borne Flavivirus, which infects cells through clathrin-mediated endocytosis and fusion employing acidic endosomes. Cell entry is mostly mediated by the viral glycoprotein E, although incomplete particle maturation enables viral protein prM and anionic lipids present in the viral membrane to mediate this process. Incomplete proteolytic maturation results in a set of highly heterogeneous particles. These heterogeneous and dynamic infectious particles offer a variety of possible receptor interaction sites on their surfaces, thus contributing to the wide range of cells susceptible to ZIKV as well as to variation in tissue tropism. This review addresses recent advances in the understanding of ZIKV entry process into cells and put together fundamental questions about viral replication, maturation and host-cell interactions.
引用
收藏
页码:22 / 29
页数:8
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