Computer keyboard interaction as an indicator of early Parkinson's disease

被引:73
作者
Giancardo, L. [1 ]
Sanchez-Ferro, A. [1 ,2 ,3 ,4 ,5 ]
Arroyo-Gallego, T. [1 ,6 ]
Butterworth, I. [1 ]
Mendoza, C. S. [1 ]
Montero, P. [7 ]
Matarazzo, M. [2 ,3 ,4 ,5 ]
Obeso, J. A. [2 ,3 ,4 ]
Gray, M. L. [1 ,8 ]
Estepar, R. San Jose [9 ]
机构
[1] MIT, Elect Res Lab, Madrid MIT M Vis Consortium, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[2] HM Hosp, Ctr Integral Neurociencias HM CINAC, Madrid, Spain
[3] CEU San Pablo Univ, Campus Moncloa,Calle Julian Romea 18, Madrid 28003, Spain
[4] Ctr Invest Biomed Red, Enfermedades Neurodegenerat CIBERNED, Madrid, Spain
[5] Inst Invest Hosp 12 Octubre I 12, Madrid, Spain
[6] Univ Politecn Madrid, E-28040 Madrid, Spain
[7] Hosp Clin San Carlos, Movement Disorders Unit, Madrid, Spain
[8] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA
关键词
MORTALITY; DYNAMICS; TRIALS;
D O I
10.1038/srep34468
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Parkinson's disease (PD) is a slowly progressing neurodegenerative disease with early manifestation of motor signs. Objective measurements of motor signs are of vital importance for diagnosing, monitoring and developing disease modifying therapies, particularly for the early stages of the disease when putative neuroprotective treatments could stop neurodegeneration. Current medical practice has limited tools to routinely monitor PD motor signs with enough frequency and without undue burden for patients and the healthcare system. In this paper, we present data indicating that the routine interaction with computer keyboards can be used to detect motor signs in the early stages of PD. We explore a solution that measures the key hold times (the time required to press and release a key) during the normal use of a computer without any change in hardware and converts it to a PD motor index. This is achieved by the automatic discovery of patterns in the time series of key hold times using an ensemble regression algorithm. This new approach discriminated early PD groups from controls with an AUC = 0.81 (n = 42/43; mean age = 59.0/60.1; women = 43%/60%; PD/controls). The performance was comparable or better than two other quantitative motor performance tests used clinically: alternating finger tapping (AUC = 0.75) and single key tapping (AUC = 0.61).
引用
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页数:10
相关论文
共 35 条
[1]   Keystroke dynamics in the pre-touchscreen era [J].
Ahmad, Nasir ;
Szymkowiak, Andrea ;
Campbell, Paul A. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2013, 7
[2]   Detecting and monitoring the symptoms of Parkinson's disease using smartphones: A pilot study [J].
Arora, S. ;
Venkataraman, V. ;
Zhan, A. ;
Donohue, S. ;
Biglan, K. M. ;
Dorsey, E. R. ;
Little, M. A. .
PARKINSONISM & RELATED DISORDERS, 2015, 21 (06) :650-653
[3]   Measuring motor speed through typing: a surrogate for the finger tapping test [J].
Austin, Daniel ;
Jimison, Holly ;
Hayes, Tamara ;
Mattek, Nora ;
Kaye, Jeffrey ;
Pavel, Misha .
BEHAVIOR RESEARCH METHODS, 2011, 43 (04) :903-909
[4]   Biometric Authentication and Identification using Keystroke Dynamics: A Survey [J].
Banerjee, Salil P. ;
Woodard, Damon L. .
JOURNAL OF PATTERN RECOGNITION RESEARCH, 2012, 7 (01) :116-139
[5]   The PRIPS study: screening battery for subjects at risk for Parkinson's disease [J].
Berg, D. ;
Godau, J. ;
Seppi, K. ;
Behnke, S. ;
Liepelt-Scarfone, I. ;
Lerche, S. ;
Stockner, H. ;
Gaenslen, A. ;
Mahlknecht, P. ;
Huber, H. ;
Srulijes, K. ;
Klenk, J. ;
Fassbender, K. ;
Maetzler, W. ;
Poewe, W. .
EUROPEAN JOURNAL OF NEUROLOGY, 2013, 20 (01) :102-108
[6]  
Bishop C. M., 2007, Technometrics, DOI DOI 10.1198/TECH.2007.S518
[7]   LIBSVM: A Library for Support Vector Machines [J].
Chang, Chih-Chung ;
Lin, Chih-Jen .
ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY, 2011, 2 (03)
[8]   COMPLIANCE DECLINES BETWEEN CLINIC VISITS [J].
CRAMER, JA ;
SCHEYER, RD ;
MATTSON, RH .
ARCHIVES OF INTERNAL MEDICINE, 1990, 150 (07) :1509-1510
[9]   Subjective complaints, precede Parkinson disease - The Rotterdam study [J].
de Lau, LML ;
Koudstaal, PJ ;
Hofman, A ;
Breteler, MMB .
ARCHIVES OF NEUROLOGY, 2006, 63 (03) :362-365
[10]  
File T., 2014, CURRENT POPULATION S