Thermoresponsive polysaccharides and their thermoreversible physical hydrogel networks

被引:151
作者
Graham, Sarah [1 ]
Marina, Paula Facal [1 ,2 ]
Blencowe, Anton [1 ,2 ]
机构
[1] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA 5000, Australia
[2] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia
关键词
Thermoresponsive; Polysaccharides; Hydrogel; Sol-gel; Polymers; Biomaterials; CHITOSAN-BASED HYDROGEL; MESENCHYMAL STEM-CELLS; THERMOSENSITIVE HYDROGEL; GRAFT-COPOLYMERS; HYDROXYBUTYL CHITOSAN; GUAR GUM; ISOPROPYLACRYLAMIDE COPOLYMER; N-ISOPROPYLACRYLAMIDE; INJECTABLE HYDROGEL; CARBOXYMETHYL GUAR;
D O I
10.1016/j.carbpol.2018.11.053
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Thermoresponsive polymers have been used extensively for various applications including food additives, pharmaceutical formulations, therapeutic delivery, cosmetics and environmental remediation, to mention a few. Many thermoresponsive polymers have the ability to form physical hydrogel networks in response to temperature changes, which are particularly useful for emerging biomedical applications, including cell therapies, drug delivery systems, tissue engineering, wound healing and 3D bioprinting. In particular, the use of polysaccharides with thermoresponsive properties has been of interest due to their wide availability, versatile functionality, biodegradability, and in many cases, inherent biocompatibility. Naturally thermoresponsive polysaccharides include agarose, carrageenans and gellan gum, which exhibit upper critical solution temperatures, transitioning from a solution to a gel state upon cooling. Arguably, this limits their use in biomedical applications, particularly for cell encapsulation as they require raised temperatures to maintain a solution state that may be detrimental to living systems. Conversely, significant progress has been made over recent years to develop synthetically modified polysaccharides, which tend to exhibit lower critical solution temperatures, transitioning from a solution to a gel state upon warming. Of particular interest are thermoresponsive polysaccharides with a lower critical solution temperature in between room temperature and physiological temperature, as their solutions can conveniently be manipulated at room temperature before gelling upon warming to physiological temperature, which makes them ideal candidates for many biological applications. Therefore, this review provides an introduction to the different types of thermoresponsive polysaccharides that have been developed, their resulting hydrogels and properties, and the exciting applications that have emerged as a result of these properties.
引用
收藏
页码:143 / 159
页数:17
相关论文
共 133 条
  • [1] [Anonymous], 1997, ADV POLYM SCI, V130, P194
  • [2] [Anonymous], FOOD COLLOIDS
  • [3] [Anonymous], 2017, GELS
  • [4] [Anonymous], MACROMOLECULAR MAT E
  • [5] [Anonymous], 1995, RHEOLOGY IND POLYSAC, DOI DOI 10.1007/978-1-4615-2185-3_4
  • [6] [Anonymous], 2012, CHITOSAN ITS DERIVAT
  • [7] [Anonymous], MACROMOLECULAR BIOSC
  • [8] [Anonymous], 2010, FOOD STABILISERS THI
  • [9] [Anonymous], MOL BIOL PRINCIPLES
  • [10] [Anonymous], WORKSH MAR ALG BIOT