Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials

被引：91

作者：

Ranieri, Michael R. M. ^{[1
,2
]}

Whitchurch, Cynthia B. ^{[3
]}

Burrows, Lori L. ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

[2] McMaster Univ, Michael G DeGroote Inst Infect Dis Res, Hamilton, ON, Canada

[3] Univ Technol Sydney, Ithree Inst, Sydney, NSW, Australia

来源：

CURRENT OPINION IN MICROBIOLOGY | 2018年 / 45卷

关键词：

EXTRACELLULAR DNA; ANTIBIOTICS; PATHOGENS; STRESS; TARGET;

D O I：

10.1016/j.mib.2018.07.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Biofilms are a typical mode of growth for most microorganisms and provide them with a variety of survival benefits. Biofilms can pose medical and industrial challenges due to their increased tolerance of antimicrobials and disinfectants. Exposure of bacteria to subinhibitory concentrations of those compounds can further exacerbate the problem, as they provoke physiological changes that lead to increased biofilm production and potential therapeutic failure. The protected niche of a biofilm provides conditions that promote selection for persisters and resistant mutants. In this review we discuss our current understanding of the mechanisms underlying biofilm stimulation in response to subinhibitory antimicrobials, and how we might exploit this 'anti-antibiotic' phenotype to treat biofilm-related infections and discover new compounds.

引用

页码：164 / 169

页数：6

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