Antiviral Immunity in SARS-CoV-2 Infection: From Protective to Deleterious Responses

被引：0
作者：
Mihaescu, Grigore [1 ]
Chifiriuc, Mariana Carmen [1 ,2 ,3 ]
Vrancianu, Corneliu Ovidiu [1 ]
Constantin, Marian [4 ]
Filip, Roxana [5 ,6 ]
Popescu, Mihaela Roxana [7 ]
Burlibasa, Liliana [1 ]
Nicoara, Anca Cecilia [8 ]
Bolocan, Alexandra [9 ]
Iliescu, Ciprian [10 ,11 ,12 ]
Gradisteanu Pircalabioru, Gratiela [2 ]
机构：
[1] Univ Bucharest, Fac Biol, Bucharest 030018, Romania
[2] Univ Bucharest, Life Environm & Earth Sci Div, Res Inst, Bucharest 050096, Romania
[3] Romanian Acad, 25 Calea Victoriei,Sect 1, Bucharest 010071, Romania
[4] Inst Biol, Bucharest 060031, Romania
[5] Stefan Cel Mare Univ Suceava, Fac Med & Biol Sci, Suceava 720229, Romania
[6] Reg Cty Emergency Hosp, Suceava 720284, Romania
[7] Univ Med & Pharm Carol Davila, Elias Emergency Univ Hosp Carol Davila, Dept Cardiol, Bucharest 020021, Romania
[8] Univ Med & Pharm Carol Davila, Fac Pharm, Bucharest 020021, Romania
[9] Univ Med & Pharm Carol Davila, Gen Surg, Bucharest 020021, Romania
[10] Natl Inst Res & Dev Microtechnol IMT, Bucharest 077190, Romania
[11] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Bucharest 011061, Romania
[12] Acad Romanian Scientists, Bucharest 010071, Romania
来源：
MICROORGANISMS | 2021年 / 9卷 / 12期
关键词：
immune response; antiviral; SARS-CoV-2; lymphocytes; antibodies; inflammation; CYTOKINE STORMS; T-CELLS; COVID-19; CORONAVIRUSES; MECHANISMS; DISEASE; POINT; LABEL; AXIS; BATS;
D O I：
10.3390/microorganisms9122578
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
After two previous episodes, in 2002 and 2012, when two highly pathogenic coronaviruses (SARS, MERS) with a zoonotic origin emerged in humans and caused fatal respiratory illness, we are today experiencing the COVID-19 pandemic produced by SARS-CoV-2. The main question of the year 2021 is if naturally- or artificially-acquired active immunity will be effective against the evolving SARS-CoV-2 variants. This review starts with the presentation of the two compartments of antiviral immunity-humoral and cellular, innate and adaptive-underlining how the involved cellular and molecular actors are intrinsically connected in the development of the immune response in SARS-CoV-2 infection. Then, the SARS-CoV-2 immunopathology, as well as the derived diagnosis and therapeutic approaches, will be discussed.
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页数：22
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