Structural synaptic plasticity in the hippocampus induced by spatial experience and its implications in information processing

被引：7

作者：

Carasatorre, M. ^{[1
]}

Ramirez-Amaya, V. ^{[1
]}

Diaz Cintra, S. ^{[2
]}

机构：

[1] Inst Neurobiol INB, Dept Neurobiol Conductual & Cognit, Campus UNAM Juriquilla, Queretaro, Mexico

[2] Inst Neurobiol INB, Dept Neurobiol Desarrollo & Neurofisiol, Campus UNAM Juriquilla, Queretaro, Mexico

来源：

NEUROLOGIA | 2016年 / 31卷 / 08期

关键词：

Synaptic plasticity; Hippocampus; Spatial experience; Long-term memory; Neuronal ensembles; Mossy fibres; MOSSY FIBER SYNAPTOGENESIS; LONG-TERM POTENTIATION; CA1 PYRAMIDAL CELLS; 2 RAT STRAINS; DENTATE GYRUS; PERFORANT PATH; MEMORY CONSOLIDATION; SWIMMING NAVIGATION; PATTERN SEPARATION; MICE;

D O I：

10.1016/j.nrl.2012.12.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Long-lasting memory formation requires that groups of neurons processing new information develop the ability to reproduce the patterns of neural activity acquired by experience. Development: Changes in synaptic efficiency let neurons organise to form ensembles that repeat certain activity patterns again and again. Among other changes in synaptic plasticity, structural modifications tend to be long-lasting which suggests that they underlie long-term memory. There is a large body of evidence supporting that experience promotes changes in the synaptic structure, particularly in the hippocampus. Conclusion: Structural changes to the hippocampus may be functionally implicated in stabilising acquired memories and encoding new information. (C) 2012 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：543 / 549

页数：7

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