The emerging role of the lkaros stem cell factor in the neuroendocrine system

被引：11
作者：
Ezzat, Shereen [1 ]
Asa, Sylvia L. [2 ]
机构：
[1] Princess Margaret Hosp, Ontario Canc Inst, Dept Med, Univ Hlth Network, Toronto, ON M5G 1X5, Canada
[2] Princess Margaret Hosp, Ontario Canc Inst, Dept Pathobiol, Univ Hlth Network, Toronto, ON M5G 1X5, Canada
来源：
JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2008年 / 41卷 / 1-2期
关键词：
D O I：
10.1677/JME-08-0045
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review, we cover the evidence implicating Ikaros as a key factor whose transcriptional actions and chromatin remodeling properties determine the fate of hypothalamic neuroendocrine and pituitary cell population expansion. We propose that the governing mechanisms involved in the regulation and action of lkaros are of importance during developmental as well as neoplastic transitions.
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收藏
页码：45 / 51
页数：7
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