Single cell mechanics: Stress stiffening and kinematic hardening

被引：53

作者：

Fernandez, Pablo ^{[1
]}

Ott, Albrecht ^{[1
]}

机构：

[1] Univ Bayreuth, Inst Phys, D-95440 Bayreuth, Germany

来源：

PHYSICAL REVIEW LETTERS | 2008年 / 100卷 / 23期

关键词：

D O I：

10.1103/PhysRevLett.100.238102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the complex rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic kinematic hardening. Despite the complexity of the living cell, its mechanical properties can be cast into simple, well-defined rules. Our results reveal the key role of crosslink slippage in determining mechanical cell strength and robustness.

引用

页数：4

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