Clinical evaluations of mineralized collagen in the extraction sites preservation

被引：28

作者：

Feng, Lu ^{[1
,2
]}

Zhang, Liang ^{[3
]}

Cui, Yun ^{[4
]}

Song, Tian-Xi ^{[4
]}

Qiu, Zhi-Ye ^{[4
,5
]}

Wang, Xiu-Mei ^{[5
]}

Tan, Bao-Sheng ^{[2
]}

机构：

[1] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Stomatol, Beijing 100700, Peoples R China

[2] Capital Med Univ, Beijing Stomatol Hosp, Beijing 100050, Peoples R China

[3] Gen Hosp Beijing Mil Reg, Outpatient Dept 2, Beijing 100125, Peoples R China

[4] Beijing AlIgens Med Sci & Technol Co Ltd, Beijing 100176, Peoples R China

[5] Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China

来源：

REGENERATIVE BIOMATERIALS | 2016年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

mineralized collagen; biomimetic; extraction site preservation; bone formation height; TOOTH EXTRACTION; BONE REGENERATION; ALVEOLAR BONE; IN-VITRO;

D O I：

10.1093/rb/rbv027

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The purpose of this study was to explore the different effects between biomimetic mineralized collagen (MC) and ordinary physically blended hydroxyapatite/collagen (HA/Col) composite in evaluating new bone formation and regenerated bone height in human extraction sockets. Thirty-four patients who cannot retain teeth caused by trauma or decay were randomly selected from Department of Stomatology of Dongzhimen Hospital from December 2013 to December 2014. The patients were randomly divided into two groups. After the operation of tooth extraction, 17 patients were implanted with biomimetic MC (MC group), and other 17 patients were implanted with ordinary physically blended nHA/Col composite (nHA/Col group). X-ray positioning projection by auto-photographing was taken to test the distance between the lowest position and the neighboring CEJm-CEJd immediately, 1 month and 3 months after the operation. The height of new bone formation of the MC group was significantly higher than the nHA/Col group. Biomimetic MC showed better clinical outcomes in the bone formation for extraction site preservation and would have broad application prospect in the field of oral and maxillofacial surgeries.

引用

页码：41 / 48

页数：8

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