Treatment for Eradication of Helicobacter pylori Infection among Chronic Hepatitis C Patients

被引：10

作者：

Furusyo, Norihiro ^{[1
,2
]}

Walaa, Ahmed H. ^{[2
]}

Eiraku, Kunimitsu ^{[2
]}

Toyoda, Kazuhiro ^{[1
]}

Ogawa, Eiichi ^{[1
]}

Ikezaki, Hiroaki ^{[2
]}

Ihara, Takeshi ^{[2
]}

Hayashi, Takeo ^{[2
]}

Kainuma, Mosaburo ^{[1
,2
]}

Murata, Masayuki ^{[1
]}

Hayashi, Jun ^{[1
,2
]}

机构：

[1] Kyushu Univ Hosp, Dept Gen Internal Med, Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Dept Environm Med & Infect Dis, Fukuoka 812, Japan

来源：

GUT AND LIVER | 2011年 / 5卷 / 04期

关键词：

Helicobacter pylori; Chronic hepatitis C; PEPTIC-ULCER; TRANSCRIPTION ELONGATION; METRONIDAZOLE RESISTANCE; JAPAN; POPULATION; VIRUS; CLARITHROMYCIN; TRANSMISSION; GASTRITIS; LOCALIZATION;

D O I：

10.5009/gnl.2011.5.4.447

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Helicobacter pylori infection causes gastritis, peptic ulcers and gastric malignancies, and its eradication has been advocated by many groups. We determined the H. pylon carrier status and eradication rates of patients with chronic hepatitis C virus (HCV) infection. Methods: In total, 76 chronically HCV-infected patients were enrolled for comparison with 228 HCV-noninfected, age- and sex-matched controls. H. pylori infection was confirmed by H. pylori antibody and urea breath testing. Results: The H. pylon infection rate was significantly higher for HCV-infected patients (67 of 76, 88.2%) than for HCV-noninfected controls (158 of 228, 69.3%). Endoscopic findings showed that the rates of gastric ulcers and gastritis were significantly higher for the 67 HCV-infected patients with H. pylori infection (34.3% and 77.6%) than for the 158 HCV-noninfected controls with H. pylon infection (15.2% and 57.6%). Treatment to eradicate H. pylon had a significantly higher success rate for HCV-infected patients (61 of 67, 91.0%) than for HCV-noninfected controls (115 of 158, 72.8%). Conclusions: The markedly high H. pylori eradication rate observed in this study shows that eradication of H. pylon holds promise for the improvement of the long-term health condition of patients with chronic HCV infection. (Gut Liver 2011;5:447-453)

引用

页码：447 / 453

页数：7