Association analysis of serotonin and catecholamine system candidate genes in obsessive-compulsive disorder in the Chinese population

被引：17

作者：

Liu, Wei ^{[1
]}

Zhao, Na ^{[1
]}

Xiong, Jidong ^{[2
]}

Shi, Mei ^{[1
]}

Hu, Jian ^{[1
]}

机构：

[1] Harbin Med Coll, Affiliated Hosp 1, Dept Psychiat & Psychol, Harbin 150001, Peoples R China

[2] Harbin Med Coll, Affiliated Hosp 4, Dept Gen Surg, Harbin 150001, Peoples R China

来源：

PSYCHIATRY RESEARCH | 2011年 / 188卷 / 01期

关键词：

Genetic; Obsessive-compulsive disorder; Polymorphism; FAMILY-BASED ASSOCIATION; O-METHYLTRANSFERASE POLYMORPHISM; 5-HT2A PROMOTER POLYMORPHISM; 5-HT1D-BETA RECEPTOR GENE; NO ASSOCIATION; FUNCTIONAL POLYMORPHISM; COMT; DOPAMINE; ALLELE; SCHIZOPHRENIA;

D O I：

10.1016/j.psychres.2010.08.030

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Serotonin and catecholamine system studies provide increasing evidence for the importance of genetic factors in obsessive-compulsive disorder (OCD); we found that genetic linkage disequilibrium with OCD existed in the 5-HT2A-receptor promoter polymorphism -1438G/A. The results of our research strongly suggested that the -1438G/A promoter polymorphism plays a role in the psychopathology of OCD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：170 / 172

页数：3

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