Immunology and zebrafish: Spawning new models of human disease

被引：232
作者：
Meeker, Nathan D. [1 ]
Trede, Nikolaus S.
机构：
[1] Univ Utah, Dept Pediat, Salt Lake City, UT 84112 USA
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2008年 / 32卷 / 07期
关键词：
animal models; infection; immunodeficiency; leukemia; adaptive immunity; innate immunity; forward genetic screen;
D O I：
10.1016/j.dci.2007.11.011
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
The zebrafish has emerged as a powerful new vertebrate model of human disease. Initially prominent in developmental biology, the zebrafish has now been adopted into varied fields of study including immunology. In this review, we describe the characteristics of the zebrafish, which make it a versatile model, including a description of its immune system with its remarkable similarities to its mammalian counterparts. We review the zebrafish disease models of innate and adaptive immunity. Models of immune system malignancies are discussed that are either based on oncogene over-expression or on our own forward-genetic screen that was designed to identify new models of immune dysregulation. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：745 / 757
页数：13
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