The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

被引：48
|
作者：
Membreno, Fernando E. [1 ]
Lawitz, Eric J. [1 ]
机构：
[1] Alamo Med Res, San Antonio, TX 78215 USA
来源：
CLINICS IN LIVER DISEASE | 2011年 / 15卷 / 03期
关键词：
Hepatitis C virus; NS5B nucleoside inhibitors; Non-nucleoside inhibitors; Polymerase inhibitors; HEPATITIS-C VIRUS; RNA-POLYMERASE INHIBITOR; ANTIVIRAL EFFICACY; HCVNS5B POLYMERASE; RESISTANCE; PROTEASE; INFECTION; PHARMACOKINETICS; PEGINTERFERON; TELAPREVIR;
D O I：
10.1016/j.cld.2011.05.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical trials. Direct-acting antiviral combination trials that have already shown some early promising results even in the setting of interferon-sparing antiviral regimens are discussed.
引用
收藏
页码：611 / +
页数：17
相关论文
共 50 条
  • [31] Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase
    Rouviere, Claire Pierra
    Amador, Agnes
    Badaroux, Eric
    Convard, Thierry
    Da Costa, Daniel
    Dukhan, David
    Griffe, Ludovic
    Griffon, Jean-Francois
    LaColla, Massimiliano
    Leroy, Frederic
    Liuzzi, Michel
    Loi, Anna Giulia
    McCarville, Joe
    Mascia, Valeria
    Milhau, Julien
    Onidi, Loredana
    Paparin, Jean-Laurent
    Rahali, Rachid
    Sais, Efisio
    Seifer, Maria
    Surleraux, Dominique
    Standring, David
    Dousson, Cyril
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (18) : 4536 - 4541
  • [32] Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors
    Rydberg, Edwin H.
    Cellucci, Antonella
    Bartholomew, Linda
    Mattu, Marco
    Barbato, Gaetano
    Ludmerer, Steven W.
    Graham, Donald J.
    Altamura, Sergio
    Paonessa, Giacomo
    De Francesco, Raffaele
    Migliaccio, Giovanni
    Carfi, Andrea
    JOURNAL OF MOLECULAR BIOLOGY, 2009, 390 (05) : 1048 - 1059
  • [33] A non-nucleoside inhibitor of BVDV replication targeted to a novel noncatalytic region within NS5b polymerase
    LaFemina, R
    Wolanski, B
    Fay, JF
    Graham, DJ
    Ludmerer, SW
    McMasters, DR
    Carroll, SS
    Tomassini, J
    Flores, OA
    ANTIVIRAL THERAPY, 2002, 7 (04) : L102 - L102
  • [34] PRECLINICAL CHARACTERIZATION OF THE HEPATITIS C VIRUS NS5B POLYMERASE NON-NUCLEOSIDE INHIBITOR BILB 1941
    Kukolj, G.
    Anderson, P. C.
    Boes, M.
    Cordingley, M. G.
    Coulombe, R.
    Garneau, M.
    Gillard, J.
    Goulet, S.
    Jolicoeur, E.
    Lagace, L.
    Lamarre, D.
    Laplante, S.
    Marquis, M.
    McKercher, G.
    Pellerin, C.
    Poupart, M. -A.
    Beaulieu, P. L.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S480 - S480
  • [35] Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase
    Giuliano, C
    Fiore, F
    Di Marco, A
    Velazquez, JP
    Bishop, A
    Bonelli, F
    Gonzalez-Paz, O
    Marcucci, I
    Harper, S
    Narjes, F
    Pacini, B
    Monteagudo, E
    Migliaccio, G
    Rowley, M
    Laufer, R
    XENOBIOTICA, 2005, 35 (10-11) : 1035 - 1054
  • [36] PATTERNS OF NS5B MUTATIONS IN A 3-DAY CLINICAL TRIAL OF HCV NON-NUCLEOSIDE POLYMERASE INHIBITOR IDX375
    McCarville, Joseph
    Gillum, Joshua M.
    Seifer, Maria
    Dumbrava, Vlada-Tatiana
    Pietropaolo, Keith
    Sullivan-Bolyai, John
    Standring, David N.
    HEPATOLOGY, 2011, 54 : 542A - 543A
  • [37] HCV nucleoside NS5B polymerase inhibitors: antiviral activities and barriers to resistance among different HCV genotype and subtypes
    Mo, H.
    ANTIVIRAL THERAPY, 2014, 19 : A21 - A21
  • [38] Non-nucleoside inhibitors of NS5B polymerase binding to allosteric sites: 3D-QSAR and molecular docking studies
    Cao, Hongyu
    Cao, Ran
    Zhang, Huabei
    Zheng, Xuefang
    Gao, Dabin
    CURRENT MEDICINAL CHEMISTRY, 2008, 15 (15) : 1462 - 1477
  • [39] Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase (vol 55, pg 2481, 2012)
    Sofia, Michael J.
    Chang, Wonsuk
    Furman, Phillip A.
    Mosley, Ralph T.
    Ross, Bruce S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (07) : 3219 - 3219
  • [40] PRECLINICAL CHARACTERIZATION OF THE HEPATITIS C VIRUS NS5B POLYMERASE NON-NUCLEOSIDE INHIBITOR BI 207127
    Beaulieu, P. L.
    Anderson, P. C.
    Brochu, C.
    Boes, M.
    Cordingley, M.
    Duan, J.
    Garneau, M.
    Lagrace, L.
    Marquis, M.
    McKercher, G.
    Poupart, B.
    Rancourt, J.
    Stammers, T.
    Tsantrizos, Y. S.
    Kukolj, G.
    JOURNAL OF HEPATOLOGY, 2012, 56 : S321 - S321
12345