The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

被引：48

作者：

Membreno, Fernando E. ^{[1
]}

Lawitz, Eric J. ^{[1
]}

机构：

[1] Alamo Med Res, San Antonio, TX 78215 USA

来源：

CLINICS IN LIVER DISEASE | 2011年 / 15卷 / 03期

关键词：

Hepatitis C virus; NS5B nucleoside inhibitors; Non-nucleoside inhibitors; Polymerase inhibitors; HEPATITIS-C VIRUS; RNA-POLYMERASE INHIBITOR; ANTIVIRAL EFFICACY; HCVNS5B POLYMERASE; RESISTANCE; PROTEASE; INFECTION; PHARMACOKINETICS; PEGINTERFERON; TELAPREVIR;

D O I：

10.1016/j.cld.2011.05.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical trials. Direct-acting antiviral combination trials that have already shown some early promising results even in the setting of interferon-sparing antiviral regimens are discussed.

引用

页码：611 / +

页数：17

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