In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp.

被引：15

作者：

Raffetin, A. ^{[1
,2
]}

Courbin, V. ^{[1
,3
]}

Jullien, V. ^{[4
,5
]}

Dannaoui, E. ^{[1
,5
]}

机构：

[1] Hop Europeen Georges Pompidou, AP HP, Unite Parasitol Mycol, Serv Microbiol, Paris, France

[2] Univ Paris 06, Paris 6, Paris, VI, Australia

[3] Univ Paris Sud, UFR Pharm, Chatenay Malabry, France

[4] Hop Europeen Georges Pompidou, AP HP, Serv Pharmacol, Paris, France

[5] Univ Paris 05, Fac Med, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 01期

关键词：

isavuconazole; echinocandins; Aspergillus spp; EUCAST; gradient strips; MIC; combination; GUINEA-PIG MODEL; AMPHOTERICIN-B; VORICONAZOLE; FUMIGATUS; ANIDULAFUNGIN; EFFICACY; CASPOFUNGIN; MICAFUNGIN; ITRACONAZOLE; MANAGEMENT;

D O I：

10.1128/AAC.01382-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In vitro combinations of isavuconazole with echinocandins were evaluated against 30 Aspergillus strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.

引用

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