In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp.

被引：15
作者：
Raffetin, A. [1 ,2 ]
Courbin, V. [1 ,3 ]
Jullien, V. [4 ,5 ]
Dannaoui, E. [1 ,5 ]
机构：
[1] Hop Europeen Georges Pompidou, AP HP, Unite Parasitol Mycol, Serv Microbiol, Paris, France
[2] Univ Paris 06, Paris 6, Paris, VI, Australia
[3] Univ Paris Sud, UFR Pharm, Chatenay Malabry, France
[4] Hop Europeen Georges Pompidou, AP HP, Serv Pharmacol, Paris, France
[5] Univ Paris 05, Fac Med, Paris, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 01期
关键词：
isavuconazole; echinocandins; Aspergillus spp; EUCAST; gradient strips; MIC; combination; GUINEA-PIG MODEL; AMPHOTERICIN-B; VORICONAZOLE; FUMIGATUS; ANIDULAFUNGIN; EFFICACY; CASPOFUNGIN; MICAFUNGIN; ITRACONAZOLE; MANAGEMENT;
D O I：
10.1128/AAC.01382-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In vitro combinations of isavuconazole with echinocandins were evaluated against 30 Aspergillus strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.
引用
收藏
页数：7
相关论文
共 40 条
[1]   Antifungal combination therapy - Clinical potential [J].
Baddley, JW ;
Pappas, PG .
DRUGS, 2005, 65 (11) :1461-1480
[2]   Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis [J].
Chandrasekar, PH ;
Cutright, JL ;
Manavathu, EK .
CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (10) :925-928
[3]   Prospective evaluation of azole resistance in Aspergillus fumigatus clinical isolates in France [J].
Choukri, F. ;
Botterel, F. ;
Sitterle, E. ;
Bassinet, L. ;
Foulet, F. ;
Guillot, J. ;
Costa, J. M. ;
Fauchet, N. ;
Dannaoui, E. .
MEDICAL MYCOLOGY, 2015, 53 (06) :593-596
[4]   Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania [J].
Chowdhary, Anuradha ;
Sharma, Cheshta ;
van den Boom, Mara ;
Yntema, Jan Bart ;
Hagen, Ferry ;
Verweij, Paul E. ;
Meis, Jacques F. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (11) :2979-2983
[5]   Comparative efficacies of conventional amphotericin B, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis [J].
Clemons, KV ;
Espiritu, M ;
Parmar, R ;
Stevens, DA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) :4867-4875
[6]   Combined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus [J].
Cuenca-Estrella, M ;
Gomez-Lopez, A ;
Garcia-Effron, G ;
Alcazar-Fuoli, L ;
Mellado, E ;
Buitrago, MJ ;
Rodriguez-Tudela, JL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (03) :1232-1235
[7]   In vitro evaluation of double and triple combinations of antifungal drugs against Aspergillus fumigatus and Aspergillus terreus [J].
Dannaoui, E ;
Lortholary, O ;
Dromer, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (03) :970-978
[8]   Use of spectrophotometric reading for in vitro antifungal susceptibility testing of Aspergillus spp. [J].
Dannaoui, E ;
Persat, F ;
Monier, MF ;
Borel, E ;
Piens, MA ;
Picot, S .
CANADIAN JOURNAL OF MICROBIOLOGY, 1999, 45 (10) :871-874
[9]   In vitro susceptibilities of zygomycetes to conventional and new antifungals [J].
Dannaoui, E ;
Meletiadis, J ;
Mouton, JW ;
Meis, JFGM ;
Verweij, PE .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (01) :45-52
[10]   Monotherapy or combination therapy of isavuconazole and micafungin for treating murine mucormycosis [J].
Gebremariam, Teclegiorgis ;
Wiederhold, Nathan P. ;
Alqarihi, Abdullah ;
Uppuluri, Priya ;
Azie, Nkechi ;
Edwards, John E., Jr. ;
Ibrahim, Ashraf S. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (02) :462-466
1234