NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN

被引：0
|
作者：
Naseer, Muhammad Imran [1 ]
Ullah, Ikram [1 ]
Ullah, Najeeb [1 ]
Lee, Hae Young [1 ]
Cheon, Eun Woo [2 ]
Chung, Jongil [3 ]
Kim, Myeong Ok [1 ]
机构：
[1] Gyeongsang Natl Univ, Dept Biol, Coll Nat Sci RINS & Appl Life Sci BK 21, Jinju, South Korea
[2] Int Univ Korea, Dept Food Sci, Jinju, South Korea
[3] Gyeongsang Natl Univ, Dept Agron, Jinju, South Korea
来源：
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2011年 / 24卷 / 03期
关键词：
PTZ; neurodegeneration; vitamin C; adult rat brain; INDUCED NEURONAL INJURY; CEREBRAL-ISCHEMIA; PENTYLENETETRAZOL; ACTIVATION; SEIZURE; ETHANOL; EXPRESSION; CASPASE-3; ASCORBATE; RECEPTOR;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain. We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZ-induced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult rat brain.
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页码：263 / 268
页数：6
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