Metformin can inhibit Helicobacter pylori growth

被引：23

作者：

Courtois, Sarah ^{[1
]}

Benejat, Lucie ^{[1
,2
]}

Izotte, Julien ^{[3
]}

Megraud, Francis ^{[1
,2
]}

Varon, Christine ^{[1
]}

Lehours, Philippe ^{[1
,2
]}

Bessede, Emilie ^{[1
,2
]}

机构：

[1] Univ Bordeaux, BaRITOn, Bordeaux Res Translat Oncol, INSERM,UMR 1053, F-33000 Bordeaux, France

[2] Univ Hosp Bordeaux, French Natl Reference Ctr Campylobacters & Helico, Bordeaux, France

[3] Univ Bordeaux, Anim Facil A2, Bordeaux, France

来源：

FUTURE MICROBIOLOGY | 2018年 / 13卷 / 14期

关键词：

INFECTION;

D O I：

10.2217/fmb-2018-0184

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim:Helicobacter pylori infection is a worldwide infection, its eradication rates with conventional therapies have fallen to unacceptable levels. In this context we were interested in metformin, to determine its effect on H. pylori growth. Materials & methods: Antimicrobial susceptibility tests and survival curves were performed in vitro and a H. pylori-infected mice model was used to determine metformin effect in vivo. Results:Helicobacter pylori survival and growth were decreased in presence of metformin. Furthermore, metformin-treated mice had significantly less bacteria in their stomach than the untreated mice. Conclusion: Our work is the first to demonstrate a direct antimicrobial effect of metformin on H. pylori, indicating that this molecule has not yet revealed its full potential.

引用

页码：1575 / 1584

页数：10

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