Study of acid-base equilibria of fleroxacin

被引：17
|
作者：
Popovic, G [1 ]
Milovanovic, L [1 ]
Kapetanovic, V [1 ]
机构：
[1] Univ Belgrade, Fac Pharm, Inst Inorgan & Analyt Chem, YU-11000 Belgrade, Yugoslavia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 18卷 / 4-5期
关键词：
fleroxacin; acidity constants; spectrophotometry; potentiometry;
D O I：
10.1016/S0731-7085(98)00281-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The acid-base equilibria of fleroxacin were studied by means of potentiometry and spectrophotometry. It was established that fleroxacin undergoes a complex acid-base equilibrium due to its zwitterionic nature and two proton-binding sites of similar acidity. The stoichiometric equilibrium constants were determined at 25 degrees C and constant ionic strength 0.1 M (NaCl). The acidity constants pK(1) = 5.59 +/- 0.01 and pK(2) = 8.08 +/- 0.04 were found by potentiometry, and pK(1) = 5.61 +/- 0.03 and pK(2) = 8.11 +/- 0.06 by spectrophotometry. The distribution diagram of the corresponding ionic species is given. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：859 / 863
页数：5
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