Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

被引：301
作者：
Chun, Yoomi [1 ]
Kim, Joungmok [1 ]
机构：
[1] Kyung Hee Univ, Sch Dent, Dept Oral Biochem & Mol Biol, Seoul 02447, South Korea
来源：
CELLS | 2018年 / 7卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
autophagy; autophagy adaptor; AMPK-mTORC1-ULK1; triad; PIK3C3/VPS34; regulatory modifications; PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES; REGULATES MITOCHONDRIAL DYNAMICS; NEWBORN RAT HEPATOCYTES; BECLIN; ULK1; COMPLEX; SELECTIVE AUTOPHAGY; TUMOR-GROWTH; TRANSCRIPTIONAL REGULATION; DIRECT PHOSPHORYLATION; SIGNALING PATHWAYS;
D O I：
10.3390/cells7120278
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Autophagy is a lysosome-dependent cellular degradation program that responds to a variety of environmental and cellular stresses. It is an evolutionarily well-conserved and essential pathway to maintain cellular homeostasis, therefore, dysfunction of autophagy is closely associated with a wide spectrum of human pathophysiological conditions including cancers and neurodegenerative diseases. The discovery and characterization of the kingdom of autophagy proteins have uncovered the molecular basis of the autophagy process. In addition, recent advances on the various post-translational modifications of autophagy proteins have shed light on the multiple layers of autophagy regulatory mechanisms, and provide novel therapeutic targets for the treatment of the diseases.
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页数：26
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