Multiple strategies for the treatment of invasive breast carcinoma: A comprehensive prospective

被引：6

作者：

Agarwal, Shivangi ^{[1
]}

Sau, Samaresh ^{[2
]}

Iyer, Arun K. ^{[2
,3
]}

Dixit, Anshuman ^{[4
]}

Kashaw, Sushil K. ^{[1
]}

机构：

[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Sagar, MP, India

[2] Wayne State Univ, Dept Pharmaceut Sci, Use Inspired Biomat & Integrated Nano Delivery U, Detroit, MI USA

[3] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Mol Imaging Program, Detroit, MI USA

[4] Inst Life Sci, Bhubaneswar, Odisha, India

来源：

DRUG DISCOVERY TODAY | 2022年 / 27卷 / 02期

关键词：

Synthetic derivatives; Antibody drug conjugates; Peptides; Vaccines; Antibodies; Phytopharmaceuticals; Clinical trial; TARGETING ER-ALPHA; METASTATIC BREAST; ANTITUMOR-ACTIVITY; IN-VITRO; CANCER CELLS; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL PEPTIDE; MONOCLONAL-ANTIBODY; BIOLOGICAL-ACTIVITY; INDUCED APOPTOSIS;

D O I：

10.1016/j.drudis.2021.10.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this review, we emphasize on evolving therapeutic strategies and advances in the treatment of breast cancer (BC). This includes small-molecule inhibitors under preclinical and clinical investigation, phytoconstituents with antiproliferative potential, targeted therapies as antibodies and antibody-drug conjugates (ADCs), vaccines as immunotherapeutic agents and peptides as a novel approach inhibiting the interaction of oncogenic proteins. We provide an update of molecules under different phases of clinical investigation which aid in the identification of loopholes or shortcomings that can be overcomed with future breast cancer research.

引用

页码：585 / 611

页数：27

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