The effect of external stimulation on functional networks in the aging healthy human brain

被引：13

作者：

Escrichs, Anira ^{[1
]}

Sanz Perl, Yonatan ^{[1
]}

Martinez-Molina, Noelia ^{[1
]}

Biarnes, Carles ^{[2
,3
]}

Garre-Olmo, Josep ^{[3
,4
,5
]}

Manuel Fernandez-Real, Jose ^{[3
,4
,6
,7
]}

Ramos, Rafel ^{[3
,4
,8
,9
]}

Marti, Ruth ^{[3
,8
,9
]}

Pamplona, Reinald ^{[10
]}

Brugada, Ramon ^{[3
,4
,11
]}

Serena, Joaquin ^{[3
,4
,12
]}

Ramio-Torrenta, Lluis ^{[3
,4
,12
]}

Coll-De-Tuero, Gabriel ^{[4
,8
,13
]}

Gallart, Luis ^{[14
]}

Barretina, Jordi ^{[3
]}

Vilanova, Joan C. ^{[2
,3
,4
]}

Mayneris-Perxachs, Jordi ^{[3
,6
,7
]}

Saba, Luca ^{[15
]}

Pedraza, Salvador ^{[2
,3
,4
]}

Kringelbach, Morten L. ^{[16
,17
,18
]}

Puig, Josep ^{[2
,3
,4
,5
]}

Deco, Gustavo ^{[1
,19
,20
,21
]}

机构：

[1] Univ Pompeu Fabra, Ctr Brain & Cognit, Dept Informat & Commun Technol, Computati Nal Neurc Fence Grp, Barcelona, Catalonia, Spain

[2] Hosp Univ Girona Dr Josep Trueta, Dept Radiol IDI, Girona, Spain

[3] Hosp Univ Girona Dr Josep Trueta, Girona Biomed Res Inst IDIBGI, Girona, Spain

[4] Univ Girona, Sch Med, Dept Med Sci, Girona, Spain

[5] Inst Assistencia Sanitaria, Salt, Irona, Spain

[6] Hosp Univ Girona Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, IDIBGI, Girona, Spain

[7] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Girona, Spain

[8] Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Vasc Hlth Res Grp Girona ISV Girona, Girona, Spain

[9] Catalan Inst Hlth ICS, Primary Care Serv, Girona, Spain

[10] Univ Lleida IRBLleida, Fac Med, Dept Expt Med, Lleida, Spain

[11] CIBER CV, Cardiovasc Genet Ctr, IDIBGI, Girona, Spain

[12] Hosp Univ Girona Dr Josep Trueta, Dept Neurol, Girona, Spain

[13] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[14] Girona Biomed Res Inst IDIBGI, Biobanc, Girona, Spain

[15] Univ Cagliari, Dept Radiol, AOU Cagliari, Cagliari, Italy

[16] Univ Oxford, Ctr Eudaimonia & Human Flourishing, Oxford, England

[17] Univ Oxford, Dept Psychiat, Oxford, England

[18] Aarhus Univ, Ctr Mus Brain, Dept Clin Med, Aarhus, Denmark

[19] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Catalonia, Spain

[20] Max Planck Inst Human Cognit & Brain Sci, Dept Neuropsychol, Leipzig, Germany

[21] Monash Univ, Turner Inst Brain & Mental Hlth, Melbourne, Vic, Australia

来源：

CEREBRAL CORTEX | 2022年

关键词：

aging; computational modeling; resting-state fMRI; brain states; in silico perturbations; PROBABILISTIC DIFFUSION TRACTOGRAPHY; RESTING-STATE NETWORKS; AGE-RELATED-CHANGES; TOPOLOGICAL ORGANIZATION; CONNECTIVITY; DEFAULT; CONNECTOME; FMRI; PERTURBATION; DISORDERS;

D O I：

10.1093/cercor/bhac064

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, <65 years) and older adults (N =310, >= 65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.

引用

页码：235 / 245

页数：11

共 67 条

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