Transcriptomic Analysis Reveals Abnormal Expression of Prion Disease Gene Pathway in Brains from Patients with Autism Spectrum Disorders

被引：2

作者：

Lombardo, Salvo Danilo ^{[1
]}

Battaglia, Giuseppe ^{[2
,3
]}

Petralia, Maria Cristina ^{[4
]}

Mangano, Katia ^{[1
]}

Basile, Maria Sofia ^{[1
]}

Bruno, Valeria ^{[2
,3
]}

Fagone, Paolo ^{[1
]}

Bella, Rita ^{[5
]}

Nicoletti, Ferdinando ^{[1
]}

Cavalli, Eugenio ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy

[2] Univ Sapienza, Dept Physiol & Pharmacol, Piazzale A Moro 5, I-00185 Rome, Italy

[3] IRCCS Neuromed, Localita Camerelle, I-86077 Pozzilli, Italy

[4] Univ Catania, Dept Educ Sci, I-95124 Catania, Italy

[5] Univ Catania, Dept Med Sci Surg & Adv Technol, I-95123 Catania, Italy

来源：

BRAIN SCIENCES | 2020年 / 10卷 / 04期

关键词：

autism; infection; prion; meta-analysis; MATERNAL INFECTION; FYN; DIFFERENTIATION; INVOLVEMENT; PREDICTION; PREGNANCY; MOLECULE; CHILDREN; CORM-A1; KINASE;

D O I：

10.3390/brainsci10040200

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of infections in the pathogenesis of autism spectrum disorder (ASD) is still controversial. In this study, we aimed to evaluate markers of infections and immune activation in ASD by performing a meta-analysis of publicly available whole-genome transcriptomic datasets of brain samples from autistic patients and otherwise normal people. Among the differentially expressed genes, no significant enrichment was observed for infectious diseases previously associated with ASD, including herpes simplex virus-1 (HSV-1), cytomegalovirus and Epstein-Barr virus in brain samples, nor was it found in peripheral blood from ASD patients. Interestingly, a significant number of genes belonging to the "prion diseases" pathway were found to be modulated in our ASD brain meta-analysis. Overall, our data do not support an association between infection and ASD. However, the data do provide support for the involvement of pathways related to other neurodegenerative diseases and give input to uncover novel pathogenetic mechanisms underlying ASD.

引用

页数：14

共 79 条

[1]

[Anonymous], 2019, MEDICINA LITHUANIA, DOI [DOI 10.3390/MEDICINA55100667, DOI 10.3390/medicina55100667]

[2] Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study [J].

Atladottir, Hjordis Osk ;

Henriksen, Tine Brink ;

Schendel, Diana E. ;

Parner, Erik T. .

PEDIATRICS, 2012, 130 (06) :E1447-E1454

[3] Impaired Expression of Tetraspanin 32 (TSPAN32) in Memory T Cells of Patients with Multiple Sclerosis [J].

Basile, Maria Sofia ;

Mazzon, Emanuela ;

Mangano, Katia ;

Pennisi, Manuela ;

Petralia, Maria Cristina ;

Lombardo, Salvo Danilo ;

Nicoletti, Ferdinando ;

Fagone, Paolo ;

Cavalli, Eugenio .

BRAIN SCIENCES, 2020, 10 (01)

[4] Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells [J].

Basile, Maria Sofia ;

Mazzon, Emanuela ;

Krajnovic, Tamara ;

Draca, Dijana ;

Cavalli, Eugenio ;

Al-Abed, Yousef ;

Bramanti, Placido ;

Nicoletti, Ferdinando ;

Mijatovic, Sanja ;

Maksimovic-Ivanic, Danijela .

MOLECULES, 2018, 23 (10)

[5] Syndromic autism: causes and pathogenetic pathways [J].

Benvenuto, Arianna ;

Moavero, Romina ;

Alessandrelli, Riccardo ;

Manzi, Barbara ;

Curatolo, Paolo .

WORLD JOURNAL OF PEDIATRICS, 2009, 5 (03) :169-176

[6] The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease [J].

Candido, Saverio ;

Lupo, Gabriella ;

Pennisi, Manuela ;

Basile, Maria S. ;

Anfuso, Carmelina D. ;

Petralia, Maria C. ;

Gattuso, Giuseppe ;

Vivarelli, Silvia ;

Spandidos, Demetrios A. ;

Libra, Massimo ;

Falzone, Luca .

ONCOLOGY REPORTS, 2019, 42 (03) :911-922

[7] In Silico and In Vivo Analysis of IL37 in Multiple Sclerosis Reveals Its Probable Homeostatic Role on the Clinical Activity, Disability, and Treatment with Fingolimod [J].

Cavalli, Eugenio ;

Mazzon, Emanuela ;

Basile, Maria Sofia ;

Mammana, Santa ;

Pennisi, Manuela ;

Fagone, Paolo ;

Kalfin, Reni ;

Martinovic, Vanja ;

Ivanovic, Jovana ;

Andabaka, Marko ;

Mesaros, Sarlota ;

Pekmezovic, Tatjana ;

Drulovic, Jelena ;

Nicoletti, Ferdinando ;

Petralia, Maria Cristina .

MOLECULES, 2020, 25 (01)

[8] Overexpression of Macrophage Migration Inhibitory Factor and Its Homologue D-Dopachrome Tautomerase as Negative Prognostic Factor in Neuroblastoma [J].

Cavalli, Eugenio ;

Mazzon, Emanuela ;

Mammana, Santa ;

Basile, Maria Sofia ;

Lombardo, Salvo Danilo ;

Mangano, Katia ;

Bramanti, Placido ;

Nicoletti, Ferdinando ;

Fagone, Paolo ;

Petralia, Maria Cristina .

BRAIN SCIENCES, 2019, 9 (10)

[9] Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disorders [J].

Celestino-Soper, Patricia B. S. ;

Skinner, Cindy ;

Schroer, Richard ;

Eng, Patricia ;

Shenai, Jayant ;

Nowaczyk, Malgorzata M. J. ;

Terespolsky, Deborah ;

Cushing, Donna ;

Patel, Gayle S. ;

Immken, LaDonna ;

Willis, Alecia ;

Wiszniewska, Joanna ;

Matalon, Reuben ;

Rosenfeld, Jill A. ;

Stevenson, Roger E. ;

Kang, Sung-Hae L. ;

Cheung, Sau Wai ;

Beaudet, Arthur L. ;

Stankiewicz, Pawel .

MOLECULAR CYTOGENETICS, 2012, 5

[10] Role of mycotoxins in the pathobiology of autism: A first evidence [J].

De Santis, Barbara ;

Brera, Carlo ;

Mezzelani, Alessandra ;

Soricelli, Sabina ;

Ciceri, Francesca ;

Moretti, Giorgio ;

Debegnach, Francesca ;

Bonaglia, Maria Clara ;

Villa, Laura ;

Molteni, Massimo ;

Raggi, Maria Elisabetta .

NUTRITIONAL NEUROSCIENCE, 2019, 22 (02) :132-144

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