Fabrication of bioactive glass-ceramic foams mimicking human bone portions for regenerative medicine

被引：69

作者：

Rainer, Alberto ^{[1
,2
]}

Giannitelli, Sara Maria ^{[1
]}

Abbruzzese, Franca ^{[1
]}

Traversa, Enrico ^{[2
]}

Licoccia, Silvia ^{[2
]}

Trombetta, Marcella ^{[1
]}

机构：

[1] Univ Campus Biomedico Rome, CIR Lab Chem & Biomat, I-00128 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Chem Sci & Technol, I-00133 Rome, Italy

来源：

ACTA BIOMATERIALIA | 2008年 / 4卷 / 02期

关键词：

ceramic foams; bioglass; sol-gel; 3D reconstruction; in vitro testing;

D O I：

10.1016/j.actbio.2007.08.007

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A technique for the preparation of bioglass foams for bone tissue engineering is presented. The process is based on the in situ foaming of a bioglass-loaded polyurethane foam as the intermediate step for obtaining a bioglass porous monolith, starting from sol-gel synthesized bioglass powders. The obtained foams were characterized using X-ray diffraction analysis, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy observations. The material was assessed by soaking samples in simulated body fluid and observing apatite layer formation. Diagnostic imaging taken from human patients was used to reconstruct a human bone portion, which was used to mould a tailored scaffold fabricated using the in situ foaming technique. The results confirmed that the obtained bioactive materials prepared with three-dimensional processing are promising for applications in reconstructive surgery tailored to each single patient. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：362 / 369

页数：8

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