A Regioselective Synthesis of E-Guggulsterone

被引：11

作者：

Ham, Jungyeob ^{[3
]}

Chin, Jungwook ^{[1
,2
]}

Kang, Heonjoong ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Sch Earth & Environm Sci, Ctr Marine Nat Prod & Drug Discovery, Seoul 151747, South Korea

[2] Seoul Natl Univ, Res Inst Oceanog, Seoul 151741, South Korea

[3] Korea Inst Sci & Technol, Kangnung 210340, South Korea

来源：

MOLECULES | 2011年 / 16卷 / 05期

关键词：

guggulsterone; inflammatory bowel diseases; regioselective synthesis; oppenhauer oxidation; COMMIPHORA-MUKUL; STEREOCHEMISTRY; KINASE; CELLS;

D O I：

10.3390/molecules16054165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have successfully prepared E-guggulsterone from 16,17-epoxypregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation. Additionally, isomerization was induced by heat, light (h nu) and acid catalysis to convert E-guggulsterone into the corresponding Z isomer.

引用

页码：4165 / 4171

页数：7

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