A review: Structure-activity relationship and antibacterial activities of Quinoline based hybrids

被引：46
作者：
Patel, Kajalben B. [1 ]
Kumari, Premlata [1 ]
机构：
[1] Sardar Vallabhbhai Natl Inst Technol, Dept Chem, Surat 395007, Gujarat, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1268卷
关键词：
Quinoline; Drug resistance; Antibacterial; SAR; STAPHYLOCOCCUS-AUREUS; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; HYDRAZONE DERIVATIVES; MOLECULAR DOCKING; RESISTANCE; INHIBITORS; DESIGN; PYRIMIDINE; QUINOLONES;
D O I：
10.1016/j.molstruc.2022.133634
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The drug resistance problem is most acute in the case of bacteria. There is always a need to develop novel antibacterial drugs with better mechanisms of action. Most of the quinoline-based antibiotics developed are potential antibacterial drug candidates. This review represents quinoline-based hybrids with antibacterial activity and their structure-activity relationship (SAR), which provide further insight into the improvement of quinoline-based antibiotics especially against multidrug-resistant bacterial strains. (C) 2022 Elsevier B.V. All rights reserved.
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页数：22
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