Outcome of children requiring intensive care following haematopoietic SCT for primary immunodeficiency and other non-malignant disorders

被引:23
作者
Cole, T. S. [1 ]
Johnstone, I. C. [2 ]
Pearce, M. S. [3 ]
Fulton, B. [2 ]
Cant, A. J. [1 ]
Gennery, A. R. [1 ]
Slatter, M. A. [1 ]
机构
[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Great N Childrens Hosp, Paediat Intens Care Unit, Newcastle Upon Tyne, Tyne & Wear, England
[3] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词
primary immunodeficiency; haematopoietic SCT; paediatrics; intensive care; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; MECHANICAL VENTILATION; PEDIATRIC ONCOLOGY; PROGNOSTIC-FACTORS; MEDICAL ICU; UNIT; RECIPIENTS; ADMISSION; SURVIVAL;
D O I
10.1038/bmt.2011.26
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Haematopoietic SCT (HSCT) is curative for many children with primary immunodeficiencies or other non-malignant conditions. Outcome for those admitted to intensive care following HSCT for oncology diagnoses has historically been very poor. There is no literature available specifically regarding the outcome for children with primary immunodeficiency requiring intensive care following HSCT. We reviewed our post-HSCT admission to intensive care over a 5-year period. A total of 111 children underwent HSCT. Median age at transplant was 1 year 4 months. The most common diagnosis was SCID. In all, 35% had at least one intensive care admission and 44% survived to be discharged from intensive care. Also, 73% of admission episodes requiring invasive ventilation but no inotropes or renal replacement therapy resulted in survival to discharge. Children undergoing HSCT for immunological diagnoses had a high rate of admission to intensive care. No factors were identified that could predict the need for admission. Invasive ventilation alone has a much better outcome than that in historical series. However, the need for multi-organ system support was still associated with a poor outcome. This information is useful when counselling families of children that have deteriorated and been admitted to intensive care during the HSCT procedure. Bone Marrow Transplantation (2012) 47, 40-45; doi: 10.1038/ bmt. 2011.26; published online 28 February 2011
引用
收藏
页码:40 / 45
页数:6
相关论文
共 27 条
[1]   OUTCOME OF RECIPIENTS OF BONE-MARROW TRANSPLANTS WHO REQUIRE INTENSIVE-CARE UNIT SUPPORT [J].
AFESSA, B ;
TEFFERI, A ;
HOAGLAND, HC ;
LETENDRE, L ;
PETERS, SG .
MAYO CLINIC PROCEEDINGS, 1992, 67 (02) :117-122
[2]  
DIAZ DH, 1999, BONE MARROW TRANSPL, V24, P163
[3]  
Draper E, 2010, ANN REPORT PAEDIAT I
[4]   Natural history of pulmonary complications in children after bone marrow transplantation [J].
Eikenberry, M ;
Bartakova, H ;
Defor, T ;
Haddad, IY ;
Ramsay, NKC ;
Blazar, BR ;
Milla, CE ;
Cornfield, DN .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (01) :56-64
[5]  
FABERLANGENDOEN K, 1993, BONE MARROW TRANSPL, V12, P501
[6]   Advances in hematopoietic stem cell transplantation for primary immunodeficiency [J].
Gennery, Andrew R. ;
Cant, Andrew J. .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2008, 28 (02) :439-+
[7]   Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better? [J].
Gennery, Andrew R. ;
Slatter, Mary A. ;
Grandin, Laure ;
Taupin, Pierre ;
Cant, Andrew J. ;
Veys, Paul ;
Amrolia, Persis J. ;
Gaspar, H. Bobby ;
Davies, E. Graham ;
Friedrich, Wilhelm ;
Hoenig, Manfred ;
Notarangelo, Luigi D. ;
Mazzolari, Evelina ;
Porta, Fulvio ;
Bredius, Robbert G. M. ;
Lankester, Arjen C. ;
Wulffraat, Nico M. ;
Seger, Reinhard ;
Guengoer, Tayfun ;
Fasth, Anders ;
Sedlacek, Petr ;
Neven, Benedicte ;
Blanche, Stephane ;
Fischer, Alain ;
Cavazzana-Calvo, Marina ;
Landais, Paul .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (03) :602-U342
[8]   Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002 [J].
Gennery, AR ;
Khawaja, K ;
Veys, P ;
Bredius, RGM ;
Notarangelo, LD ;
Mazzolari, E ;
Fischer, A ;
Landais, P ;
Cavazzana-Calvo, M ;
Friedrich, W ;
Fasth, A ;
Wulffraat, NM ;
Matthes-Martin, S ;
Bensoussan, D ;
Bordigoni, P ;
Lange, A ;
Pagliuca, A ;
Andolina, M ;
Cant, AJ ;
Davies, EG .
BLOOD, 2004, 103 (03) :1152-1157
[9]  
Hagen Scott A, 2003, Pediatr Crit Care Med, V4, P206, DOI 10.1097/01.PCC.0000043293.83440.79
[10]   The outcome of children requiring admission to an intensive care unit following bone marrow transplantation [J].
Hayes, C ;
Lush, RJ ;
Cornish, JM ;
Foot, AM ;
Henderson, T ;
Jenkins, I ;
Murphy, P ;
Oakhill, A ;
Pamphilon, DH ;
Steward, CG ;
Weir, P ;
Wolf, A ;
Marks, DI .
BRITISH JOURNAL OF HAEMATOLOGY, 1998, 102 (03) :666-670