Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

被引:37
|
作者
Lee, Hyo-Jung [1 ]
Kang, Ji-Hyun [1 ]
Lee, Hong-Goo [1 ]
Kim, Dong-Wook [2 ]
Rhee, Yun-Seok [3 ,4 ]
Kim, Ju-Young [5 ]
Park, Eun-Seok [6 ]
Park, Chun-Woong [1 ]
机构
[1] Chungbuk Natl Univ, Coll Pharm, 194-31,Osongsaengmyeong 1 Ro, Cheongju 28160, Chungcheongbuk, South Korea
[2] Cheongju Univ, Dept Pharmaceut Engn, Cheongju, South Korea
[3] Gyeongsang Natl Univ, Coll Pharm, Jinju, South Korea
[4] Gyeongsang Natl Univ, Pharmaceut Sci Res Inst, Jinju, South Korea
[5] Woosuk Univ, Coll Pharm, Wanju Gun, South Korea
[6] Sungkyunkwan Univ, Sch Pharm, 2066 Seobu Ro, Suwon 16419, Gyeonggi Do, South Korea
来源
DRUG DESIGN DEVELOPMENT AND THERAPY | 2016年 / 10卷
基金
新加坡国家研究基金会;
关键词
bosentan; dry powder inhalations; pulmonary arterial hypertension; respiratory drug delivery; spray drying; jet milling; DISPERSION PERFORMANCE; PARTICLES; HYPERTENSION; THERAPY; STRATEGY; DELIVERY;
D O I
10.2147/DDDT.S120356
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The objectives of this study were to prepare bosentan hydrate (BST) microparticles as dry powder inhalations (DPIs) via spray drying and jet milling under various parameters, to comprehensively characterize the physicochemical properties of the BST hydrate microparticles, and to evaluate the aerosol dispersion performance and dissolution behavior as DPIs. The BST microparticles were successfully prepared for DPIs by spray drying from feeding solution concentrations of 1%, 3%, and 5% (w/v) and by jet milling at grinding pressures of 2, 3, and 4 MPa. The physicochemical properties of the spray-dried (SD) and jet-milled (JM) microparticles were determined via scanning electron microscopy, atomic force microscopy, dynamic light scattering particle size analysis, Karl Fischer titration, surface analysis, pycnometry, differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy. The in vitro aerosol dispersion performance and drug dissolution behavior were evaluated using an Anderson cascade impactor and a Franz diffusion cell, respectively. The JM microparticles exhibited an irregular corrugated surface and a crystalline solid state, while the SD microparticles were spherical with a smooth surface and an amorphous solid state. Thus, the in vitro aerosol dispersion performance and dissolution behavior as DPIs were considerably different due to the differences in the physicochemical properties of the SD and JM microparticles. In particular, the highest grinding pressures under jet milling exhibited excellent aerosol dispersion performance with statistically higher values of 56.8%+/- 2.0% of respirable fraction and 33.8%+/- 2.3% of fine particle fraction and lower mass median aerodynamic diameter of 5.0 +/- 0.3 mu m than the others (P<0.05, analysis of variance/Tukey). The drug dissolution mechanism was also affected by the physicochemical properties that determine the dissolution kinetics of the SD and JM microparticles, which were well fitted into the Higuchi and zero-order models, respectively.
引用
收藏
页码:4017 / 4030
页数:14
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