Arylseleninic acid as a green, bench-stable selenylating agent: synthesis of selanylanilines and 3-selanylindoles

被引：17

作者：

Abenante, Laura ^{[1
]}

Padilha, Nathalia B. ^{[1
]}

Anghinoni, Joao M. ^{[1
]}

Penteado, Filipe ^{[1
]}

Rosati, Ornelio ^{[2
]}

Santi, Claudio ^{[2
]}

Silva, Marcio S. ^{[1
]}

Lenardao, Eder J. ^{[1
]}

机构：

[1] Univ Fed Pelotas UFPel, LASOL CCQFA, POB 354, BR-96010900 Pelotas, RS, Brazil

[2] Univ Perugia, Dept Pharmaceut Sci, Grp Catalysis Synth & Organ Green Chem, Via Liceo 1, I-06123 Perugia, PG, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 27期

关键词：

METAL-FREE SYNTHESIS; ANTIOXIDANT ACTIVITY; ANTIDEPRESSANT-LIKE; SELENIUM; OXIDATION; OLEFINS; ARENES; PHENYLSELENYLATION; CYCLIZATION; CONVERSION;

D O I：

10.1039/d0ob01073a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arylseleninic acids were used as an electrophilic selenium source in aromatic substitution reactions, usingN,N-substituted anilines and indoles as nucleophiles at 70 degrees C for 6-15 h. A total of fourteen 4-selanylanilines and five 3-selanylindoles were selectively obtained in good to excellent yields. The starting benzeneseleninic acids are easily prepared from the respective diselenides, are bench stable and easy to handle, affording water as the only waste at the end of the reaction.

引用

页码：5210 / 5217

页数：8

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