Synthesis, antibacterial, and antioxidant activities of naphthyl-linked disubstituted 1,2,3-triazoles

被引：19

作者：

Kaushik, Chander Prakash ^{[1
]}

Luxmi, Raj ^{[1
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar, Haryana, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 06期

关键词：

1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CLICK CHEMISTRY; DERIVATIVES; DESIGN; BEARING;

D O I：

10.1002/jhet.3956

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, click synthesis of 15 naphthyl-linked disubstituted 1,2,3-triazoles has been carried out by the reaction between 1-(prop-2-yn-1-yloxy)naphthalene and aromatic azides. The structure elucidation of the synthesized compounds was carried out by FTIR, H-1 NMR, C-13 NMR, and HRMS techniques. Further, the compound 7f was confirmed by X-ray crystallography (CCDC 1876891). The synthesized compounds were explored for antibacterial activity against Bacillus cereus, Escherichia coli, and Staphylococcus aureus. Biological evaluation of synthesized 1,2,3-triazoles revealed moderate to good antibacterial activity against the tested strains. The antioxidative behavior of synthesized compounds manifested the remarkable free radical scavenging activity using DPPH assay.

引用

页码：2400 / 2409

页数：10

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