The mitochondrial genome, paternal age and telomere length in humans

被引：13
作者：
Aviv, Abraham [1 ]
机构：
[1] Rutgers New Jersey Med Sch, Ctr Human Dev & Aging, Newark, NJ 07103 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2018年 / 373卷 / 1741期
关键词：
telomeres; father; offspring; sperm; mitochondria; evolution; MALE-DRIVEN EVOLUTION; INHERITANCE; DISEASE; SELECTION; DYNAMICS; ORIGINS; BIOLOGY; TISSUES; CELLS;
D O I：
10.1098/rstb.2017.0210
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres become longer with age. This puzzling phenomenon might explain why TL in the offspring correlates positively with paternal age. The present communication proposes that mitochondrial DNA polymorphisms and heteroplasmy cause variation in the production of reactive oxygen species, which, in turn, mediate age-dependent selection of germ stem cells with long telomeres and hence sperm with long telomeres. These long telomeres are then inherited by the offspring. The effect of paternal age on the offspring TL might be an evolutionarily driven mechanism that helps regulate TL across the human population.
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共 35 条
[21]   Telomere length assessment: Biomarker of chronic oxidative stress? [J].
Houben, Joyce M. J. ;
Moonen, Harald J. J. ;
van Schooten, Frederik J. ;
Hageman, Geja J. .
FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (03) :235-246
[22]   Telomeres and reproductive aging [J].
Keefe, David L. ;
Liu, Lin .
REPRODUCTION FERTILITY AND DEVELOPMENT, 2009, 21 (01) :10-14
[23]   Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm [J].
Kimura, Masayuki ;
Cherkas, Lynn F. ;
Kato, Bernet S. ;
Demissie, Serkalem ;
Hjelmborg, Jacob B. ;
Brimacombe, Michael ;
Cupples, Adrienne ;
Hunkin, Janice L. ;
Gardner, Jefferey P. ;
Lu, Xiaobin ;
Cao, Xiaojian ;
Sastrasinh, Malinee ;
Province, Michael A. ;
Hunt, Steven C. ;
Christensen, Kaare ;
Levy, Daniel ;
Spector, Tim D. ;
Aviv, Abraham .
PLOS GENETICS, 2008, 4 (02)
[24]   Rate of de novo mutations and the importance of father's age to disease risk [J].
Kong, Augustine ;
Frigge, Michael L. ;
Masson, Gisli ;
Besenbacher, Soren ;
Sulem, Patrick ;
Magnusson, Gisli ;
Gudjonsson, Sigurjon A. ;
Sigurdsson, Asgeir ;
Jonasdottir, Aslaug ;
Jonasdottir, Adalbjorg ;
Wong, Wendy S. W. ;
Sigurdsson, Gunnar ;
Walters, G. Bragi ;
Steinberg, Stacy ;
Helgason, Hannes ;
Thorleifsson, Gudmar ;
Gudbjartsson, Daniel F. ;
Helgason, Agnar ;
Magnusson, Olafur Th. ;
Thorsteinsdottir, Unnur ;
Stefansson, Kari .
NATURE, 2012, 488 (7412) :471-475
[25]   Male-driven evolution [J].
Li, WH ;
Yi, SJ ;
Makova, K .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (06) :650-656
[26]   Telomere lengths and telomerase activity in dog tissues: A potential model system to study human telomere and telomerase biology [J].
Nasir, L ;
Devlin, P ;
Mckevitt, T ;
Rutteman, G ;
Argyle, DJ .
NEOPLASIA, 2001, 3 (04) :351-359
[27]   Sex Differences in Sand Lizard Telomere Inheritance: Paternal Epigenetic Effects Increases Telomere Heritability and Offspring Survival [J].
Olsson, Mats ;
Pauliny, Angela ;
Wapstra, Erik ;
Uller, Tobias ;
Schwartz, Tonia ;
Blomqvist, Donald .
PLOS ONE, 2011, 6 (04)
[28]   Maternal telomere length inheritance in the king penguin [J].
Reichert, S. ;
Rojas, E. R. ;
Zahn, S. ;
Robin, J-P ;
Criscuolo, F. ;
Massemin, S. .
HEREDITY, 2015, 114 (01) :10-16
[29]   MALE-DRIVEN EVOLUTION OF DNA-SEQUENCES [J].
SHIMMIN, LC ;
CHANG, BHJ ;
LI, WH .
NATURE, 1993, 362 (6422) :745-747
[30]   Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease [J].
Stewart, James Bruce ;
Freyer, Christoph ;
Elson, Joanna L. ;
Larsson, Nils-Goeran .
NATURE REVIEWS GENETICS, 2008, 9 (09) :657-662
1234