The mitochondrial genome, paternal age and telomere length in humans

被引：13

作者：

Aviv, Abraham ^{[1
]}

机构：

[1] Rutgers New Jersey Med Sch, Ctr Human Dev & Aging, Newark, NJ 07103 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2018年 / 373卷 / 1741期

关键词：

telomeres; father; offspring; sperm; mitochondria; evolution; MALE-DRIVEN EVOLUTION; INHERITANCE; DISEASE; SELECTION; DYNAMICS; ORIGINS; BIOLOGY; TISSUES; CELLS;

D O I：

10.1098/rstb.2017.0210

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres become longer with age. This puzzling phenomenon might explain why TL in the offspring correlates positively with paternal age. The present communication proposes that mitochondrial DNA polymorphisms and heteroplasmy cause variation in the production of reactive oxygen species, which, in turn, mediate age-dependent selection of germ stem cells with long telomeres and hence sperm with long telomeres. These long telomeres are then inherited by the offspring. The effect of paternal age on the offspring TL might be an evolutionarily driven mechanism that helps regulate TL across the human population.

引用

页数：3

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