Stem cell dynamics, migration and plasticity during wound healing

被引:307
作者
Dekoninck, Sophie [1 ]
Blanpain, Cedric [1 ,2 ]
机构
[1] Univ Libre Bruxelles, Lab Stem Cells & Canc, Brussels, Belgium
[2] Univ Libre Bruxelles, WELBIO, Brussels, Belgium
基金
欧洲研究理事会;
关键词
LABEL-RETAINING CELLS; HAIR FOLLICLE REGENERATION; PROGENITOR CELLS; BETA-CATENIN; MOUSE SKIN; POPULATION; DISTINCT; REPAIR; LINEAGE; MORPHOGENESIS;
D O I
10.1038/s41556-018-0237-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem cells recruited from various skin regions together with other cell types, including fibroblasts and immune cells, is required to ensure efficient and harmonious wound healing. A complex cross-talk ensures the activation, migration and plasticity of these cells during tissue repair.
引用
收藏
页码:18 / 24
页数:7
相关论文
共 99 条
[1]   WNT signals are required for the initiation of hair follicle development [J].
Andl, T ;
Reddy, ST ;
Gaddapara, T ;
Millar, SE .
DEVELOPMENTAL CELL, 2002, 2 (05) :643-653
[2]   Defining stem cell dynamics and migration during wound healing in mouse skin epidermis [J].
Aragona, Mariaceleste ;
Dekoninck, Sophie ;
Rulands, Steffen ;
Lenglez, Sandrine ;
Mascre, Guilhem ;
Simons, Benjamin D. ;
Blanpain, Cedric .
NATURE COMMUNICATIONS, 2017, 8
[3]  
ARGYRIS TS, 1976, AM J PATHOL, V83, P329
[4]   Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes [J].
Bamberger, C ;
Schärer, A ;
Antsiferova, M ;
Tychsen, B ;
Pankow, S ;
Müller, M ;
Rülicke, T ;
Paus, R ;
Werner, S .
AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (03) :733-747
[5]   β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB [J].
Batlle, E ;
Henderson, JT ;
Beghtel, H ;
van den Born, MMW ;
Sancho, E ;
Huls, G ;
Meeldijk, J ;
Robertson, J ;
van de Wetering, M ;
Pawson, T ;
Clevers, H .
CELL, 2002, 111 (02) :251-263
[6]   Homeostasis, regeneration and tumour formation in the mammalian epidermis [J].
Belokhvostova, Daria ;
Berzanskyte, Ieva ;
Cujba, Ana-Maria ;
Jowett, Geraldine ;
Marshall, Lucy ;
Prueller, Johanna ;
Watt, Fiona M. .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2018, 62 (6-8) :571-582
[7]   Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche [J].
Blanpain, C ;
Lowry, WE ;
Geoghegan, A ;
Polak, L ;
Fuchs, E .
CELL, 2004, 118 (05) :635-648
[8]   Epidermal stem cells of the skin [J].
Blanpain, Cedric ;
Fuchs, Elaine .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :339-373
[9]   STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration [J].
Blanpain, Cedric ;
Fuchs, Elaine .
SCIENCE, 2014, 344 (6189) :1243-+
[10]   Unravelling stem cell dynamics by lineage tracing [J].
Blanpain, Cedric ;
Simons, Benjamin D. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (08) :489-502