Reaction of quinoline 1-oxides with sodium methoxide in the presence of lead(IV) acetate

被引：0

作者：

Tagawa, Y

Tanaka, K

Yamashita, K

Goto, Y

Hamana, M

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

[2] Japan Inst Heterocycl Chem, Minato Ku, Tokyo 1070051, Japan

来源：

HETEROCYCLES | 2001年 / 55卷 / 09期

关键词：

deoxygenation; N-oxide group; 2-methoxyquinoline; 1-oxide; 4-substituted; radical initiator;

D O I：

10.3987/COM-01-9295

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of lead(IV) acetate, the reaction of quinoline 1-oxide with methoxide anion under various reaction conditions gives, 2-methoxyquinoline 1-oxide without deoxygenation of A oxide group. Reaction of 4-substituted quinoline 1-oxides with methoxide anion also resulted in the corresponding 4-substituted 2-methoxyquinoline 1-oxides under the same reaction conditions. As the reaction mechanism, ionic pathway is suggested rather than radical pathway through the investigation using radical initiators.

引用

页码：1771 / +

页数：8