Human genetic susceptibility to infectious disease

被引：331
作者：
Chapman, Stephen J. [1 ]
Hill, Adrian V. S. [1 ]
机构：
[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
来源：
NATURE REVIEWS GENETICS | 2012年 / 13卷 / 03期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
GENOME-WIDE ASSOCIATION; CHRONIC HEPATITIS-C; CHRONIC MUCOCUTANEOUS CANDIDIASIS; ANHIDROTIC ECTODERMAL DYSPLASIA; PYOGENIC BACTERIAL-INFECTIONS; HERPES-SIMPLEX ENCEPHALITIS; HYPER-IGE SYNDROME; HIV-1; INFECTION; MENINGOCOCCAL DISEASE; IMMUNE-DEFICIENCY;
D O I：
10.1038/nrg3114
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence.
引用
收藏
页码：175 / 188
页数：14
相关论文
共 177 条
  • [1] Stepwise replication identifies a low-producing lymphotoxin-α allele as a major risk factor for early-onset leprosy
    Alcais, Alexandre
    Alter, Andrea
    Antoni, Guillemette
    Orlova, Marianna
    Van Thuc, Nguyen
    Singh, Meenakshi
    Vanderborght, Patricia R.
    Katoch, Kiran
    Mira, Marcelo T.
    Thai, Vu Hong
    Huong, Ngyuen Thu
    Ba, Nguyen Ngoc
    Moraes, Milton
    Mehra, Narinder
    Schurr, Erwin
    Abel, Laurent
    [J]. NATURE GENETICS, 2007, 39 (04) : 517 - 522
  • [2] Human genetics of infectious diseases: between proof of principle and paradigm
    Alcais, Alexandre
    Abel, Laurent
    Casanova, Jean-Laurent
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) : 2506 - 2514
  • [3] PROTECTION AFFORDED BY SICKLE-CELL TRAIT AGAINST SUBTERTIAN MALARIAL INFECTION
    ALLISON, AC
    [J]. BRITISH MEDICAL JOURNAL, 1954, 1 (4857) : 290 - 294
  • [4] A haplotype map of the human genome
    Altshuler, D
    Brooks, LD
    Chakravarti, A
    Collins, FS
    Daly, MJ
    Donnelly, P
    Gibbs, RA
    Belmont, JW
    Boudreau, A
    Leal, SM
    Hardenbol, P
    Pasternak, S
    Wheeler, DA
    Willis, TD
    Yu, FL
    Yang, HM
    Zeng, CQ
    Gao, Y
    Hu, HR
    Hu, WT
    Li, CH
    Lin, W
    Liu, SQ
    Pan, H
    Tang, XL
    Wang, J
    Wang, W
    Yu, J
    Zhang, B
    Zhang, QR
    Zhao, HB
    Zhao, H
    Zhou, J
    Gabriel, SB
    Barry, R
    Blumenstiel, B
    Camargo, A
    Defelice, M
    Faggart, M
    Goyette, M
    Gupta, S
    Moore, J
    Nguyen, H
    Onofrio, RC
    Parkin, M
    Roy, J
    Stahl, E
    Winchester, E
    Ziaugra, L
    Shen, Y
    [J]. NATURE, 2005, 437 (7063) : 1299 - 1320
  • [5] A map of human genome variation from population-scale sequencing
    Altshuler, David
    Durbin, Richard M.
    Abecasis, Goncalo R.
    Bentley, David R.
    Chakravarti, Aravinda
    Clark, Andrew G.
    Collins, Francis S.
    De la Vega, Francisco M.
    Donnelly, Peter
    Egholm, Michael
    Flicek, Paul
    Gabriel, Stacey B.
    Gibbs, Richard A.
    Knoppers, Bartha M.
    Lander, Eric S.
    Lehrach, Hans
    Mardis, Elaine R.
    McVean, Gil A.
    Nickerson, DebbieA.
    Peltonen, Leena
    Schafer, Alan J.
    Sherry, Stephen T.
    Wang, Jun
    Wilson, Richard K.
    Gibbs, Richard A.
    Deiros, David
    Metzker, Mike
    Muzny, Donna
    Reid, Jeff
    Wheeler, David
    Wang, Jun
    Li, Jingxiang
    Jian, Min
    Li, Guoqing
    Li, Ruiqiang
    Liang, Huiqing
    Tian, Geng
    Wang, Bo
    Wang, Jian
    Wang, Wei
    Yang, Huanming
    Zhang, Xiuqing
    Zheng, Huisong
    Lander, Eric S.
    Altshuler, David L.
    Ambrogio, Lauren
    Bloom, Toby
    Cibulskis, Kristian
    Fennell, Tim J.
    Gabriel, Stacey B.
    [J]. NATURE, 2010, 467 (7319) : 1061 - 1073
  • [6] A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese
    An, Ping
    Winkler, Cheryl
    Guan, Li
    O'Brien, Stephen J.
    Zeng, Zheng
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (07) : 943 - 947
  • [7] Host genes associated with HIV/AIDS: advances in gene discovery
    An, Ping
    Winkler, Cheryl A.
    [J]. TRENDS IN GENETICS, 2010, 26 (03) : 119 - 131
  • [8] Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesin
    Aspholm-Hurtig, M
    Dailide, G
    Lahmann, M
    Kalia, A
    Ilver, D
    Roche, N
    Vikström, S
    Sjöström, R
    Lindén, S
    Bäckström, A
    Lundberg, C
    Arnqvist, A
    Mahdavi, J
    Nilsson, UJ
    Velapatiño, B
    Gilman, RH
    Gerhard, M
    Alarcon, T
    López-Brea, M
    Nakazawa, T
    Fox, JG
    Correa, P
    Dominguez-Bello, MG
    Perez-Perez, GI
    Blaser, MJ
    Normark, S
    Carlstedt, I
    Oscarson, S
    Teneberg, S
    Berg, DE
    Borén, T
    [J]. SCIENCE, 2004, 305 (5683) : 519 - 522
  • [9] No association between interferon-γ receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample
    Awomoyi, AA
    Nejentsev, S
    Richardson, A
    Hull, J
    Koch, O
    Podinovskaia, M
    Todd, JA
    McAdam, KPWJ
    Blackwell, JM
    Kwiatkowski, D
    Newport, MJ
    [J]. THORAX, 2004, 59 (04) : 291 - 294
  • [10] Common Polymorphisms in the NOD2 Gene Region Are Associated with Leprosy and Its Reactive States
    Berrington, William Richard
    Macdonald, Murdo
    Khadge, Saraswoti
    Sapkota, Bishwa Raj
    Janer, Marta
    Hagge, Deanna Alisa
    Kaplan, Gilla
    Hawn, Thomas Richard
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (09) : 1422 - 1435
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