Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation

被引:11
|
作者
Fidalgo da Silva, E. [1 ]
Fong, J. [1 ]
Roye-Azar, A. [1 ]
Nadi, A. [1 ]
Drouillard, C. [1 ]
Pillon, A. [1 ]
Porter, L. A. [1 ]
机构
[1] Univ Windsor, Dept Biomed Sci, Windsor, ON, Canada
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 9卷
基金
加拿大自然科学与工程研究理事会;
关键词
tuberin; TSC; cell cycle; mTOR; cell growth; tuberous sclerosis complex; SCLEROSIS COMPLEX; MUTATIONAL ANALYSIS; ACTIN CYTOSKELETON; MISSENSE MUTATIONS; PRODUCT TUBERIN; MESSENGER-RNA; TSC1; GENE; C-MYC; PHOSPHORYLATION; HAMARTIN;
D O I
10.3389/fcell.2021.806521
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The ability of cells to sense diverse environmental signals, including nutrient availability and conditions of stress, is critical for both prokaryotes and eukaryotes to mount an appropriate physiological response. While there is a great deal known about the different biochemical pathways that can detect and relay information from the environment, how these signals are integrated to control progression through the cell cycle is still an expanding area of research. Over the past three decades the proteins Tuberin, Hamartin and TBC1D7 have emerged as a large protein complex called the Tuberous Sclerosis Complex. This complex can integrate a wide variety of environmental signals to control a host of cell biology events including protein synthesis, cell cycle, protein transport, cell adhesion, autophagy, and cell growth. Worldwide efforts have revealed many molecular pathways which alter Tuberin post-translationally to convey messages to these important pathways, with most of the focus being on the regulation over protein synthesis. Herein we review the literature supporting that the Tuberous Sclerosis Complex plays a critical role in integrating environmental signals with the core cell cycle machinery.
引用
收藏
页数:13
相关论文
共 50 条
  • [41] Emerging roles of metazoan cell cycle regulators as coordinators of the cell cycle and differentiation
    Kimata, Yuu
    Leturcq, Maite
    Aradhya, Rajaguru
    FEBS LETTERS, 2020, 594 (13) : 2061 - 2083
  • [42] Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation
    Miloloza, A
    Kubista, M
    Rosner, M
    Hengstschläger, M
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2002, 61 (02) : 154 - 163
  • [43] Cell Cycle Regulation by Heat Shock Transcription Factors
    Tokunaga, Yasuko
    Otsuyama, Ken-Ichiro
    Hayashida, Naoki
    CELLS, 2022, 11 (02)
  • [44] A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
    Flores-Delgado, Guillermo
    Liu, Cathy W. Y.
    Sposto, Richard
    Berndt, Norbert
    JOURNAL OF PROTEOME RESEARCH, 2007, 6 (03) : 1165 - 1175
  • [45] Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1
    Liang, H
    Hittelman, W
    Nagarajan, L
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1996, 330 (02) : 259 - 265
  • [46] Cell cycle regulation and apoptosis
    King, KL
    Cidlowski, JA
    ANNUAL REVIEW OF PHYSIOLOGY, 1998, 60 : 601 - 617
  • [47] Cell cycle regulation and hepatocarcinogenesis
    Greenbaum, LE
    CANCER BIOLOGY & THERAPY, 2004, 3 (12) : 1200 - 1207
  • [48] Cell Cycle Regulation by Integrin-Mediated Adhesion
    Kamranvar, Siamak A.
    Rani, Bhavna
    Johansson, Staffan
    CELLS, 2022, 11 (16)
  • [49] NIRF, a novel RING finger protein, is involved in cell-cycle regulation
    Mori, T
    Li, Y
    Hata, H
    Ono, K
    Kochi, H
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 296 (03) : 530 - 536
  • [50] Modeling epigenetic regulation of PRC1 protein accumulation in the cell cycle
    Marzena Dolbniak
    Marek Kimmel
    Jaroslaw Smieja
    Biology Direct, 10