Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation

被引:11
|
作者
Fidalgo da Silva, E. [1 ]
Fong, J. [1 ]
Roye-Azar, A. [1 ]
Nadi, A. [1 ]
Drouillard, C. [1 ]
Pillon, A. [1 ]
Porter, L. A. [1 ]
机构
[1] Univ Windsor, Dept Biomed Sci, Windsor, ON, Canada
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 9卷
基金
加拿大自然科学与工程研究理事会;
关键词
tuberin; TSC; cell cycle; mTOR; cell growth; tuberous sclerosis complex; SCLEROSIS COMPLEX; MUTATIONAL ANALYSIS; ACTIN CYTOSKELETON; MISSENSE MUTATIONS; PRODUCT TUBERIN; MESSENGER-RNA; TSC1; GENE; C-MYC; PHOSPHORYLATION; HAMARTIN;
D O I
10.3389/fcell.2021.806521
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The ability of cells to sense diverse environmental signals, including nutrient availability and conditions of stress, is critical for both prokaryotes and eukaryotes to mount an appropriate physiological response. While there is a great deal known about the different biochemical pathways that can detect and relay information from the environment, how these signals are integrated to control progression through the cell cycle is still an expanding area of research. Over the past three decades the proteins Tuberin, Hamartin and TBC1D7 have emerged as a large protein complex called the Tuberous Sclerosis Complex. This complex can integrate a wide variety of environmental signals to control a host of cell biology events including protein synthesis, cell cycle, protein transport, cell adhesion, autophagy, and cell growth. Worldwide efforts have revealed many molecular pathways which alter Tuberin post-translationally to convey messages to these important pathways, with most of the focus being on the regulation over protein synthesis. Herein we review the literature supporting that the Tuberous Sclerosis Complex plays a critical role in integrating environmental signals with the core cell cycle machinery.
引用
收藏
页数:13
相关论文
共 50 条
  • [21] Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death
    Lin, Yao
    Hupp, Ted R.
    Stevens, Craig
    FEBS JOURNAL, 2010, 277 (01) : 48 - 57
  • [22] Asp/ASPM phospho-regulation throughout the cell cycle
    Burns, Maria C.
    Borgal, Lori
    GENOME, 2025, 68
  • [23] Differential regulation of Akt/protein kinase B isoforms during cell cycle progression
    Yun, Sung Ji
    Tucker, David F.
    Kim, Eun Kyoung
    Kim, Min Sung
    Do, Kee Hun
    Ha, Jung Min
    Lee, Sun Young
    Yun, Jeanho
    Kim, Chi Dae
    Birnbaum, Morris J.
    Bae, Sun Sik
    FEBS LETTERS, 2009, 583 (04): : 685 - 690
  • [24] ERK implication in cell cycle regulation
    Chambard, Jean-Claude
    Lefloch, Renaud
    Pouyssegur, Jacques
    Lenormand, Philippe
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2007, 1773 (08): : 1299 - 1310
  • [25] Regulation of mRNA capping in the cell cycle
    Aregger, Michael
    Cowling, Victoria H.
    RNA BIOLOGY, 2017, 14 (01) : 11 - 14
  • [26] Lost in translation: regulation of skeletal muscle protein synthesis
    Weigl, Lukas G.
    CURRENT OPINION IN PHARMACOLOGY, 2012, 12 (03) : 377 - 382
  • [27] PAK4 Is Required for Regulation of the Cell-Cycle Regulatory Protein p21, and for Control of Cell-Cycle Progression
    Nekrasova, Tanya
    Minden, Audrey
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (07) : 1795 - 1806
  • [28] Dynamics of protein synthesis and degradation through the cell cycle
    Alber, Andrea Brigitta
    Suter, David Michael
    CELL CYCLE, 2019, 18 (08) : 784 - 794
  • [29] Protein synthesis regulation by leucine
    Vianna, Daiana
    Resende Teodoro, Gabriela Fullin
    Torres-Leal, Francisco Leonardo
    Tirapegui, Julio
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 46 (01) : 29 - 36
  • [30] Cell cycle regulation
    Garcia, Kristin
    Wichmann, Anita
    Su, Tin Tin
    FLY, 2007, 1 (02) : 125 - 131