Nicotinamide mononucleotide (NMN) as an anti-aging health product-Promises and safety concerns

被引：119
作者：
Nadeeshani, Harshani [1 ]
Li, Jinyao [2 ]
Ying, Tianlei [3 ]
Zhang, Baohong [4 ]
Lu, Jun [1 ,5 ,6 ,7 ,8 ,9 ,10 ]
机构：
[1] Auckland Univ Technol, Fac Hlth & Environm Sci, Sch Sci, Auckland 1010, New Zealand
[2] Xinjiang Univ, Coll Life Sci & Technol, Xinjiang Key Lab Biol Resources & Genet Engn, Urumqi 830046, Xinjiang, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol MOE MOH, 130 Dong An Rd, Shanghai 200032, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China
[5] Auckland Univ Technol, Fac Hlth & Environm Sci, Sch Publ Hlth & Interdisciplinary Studies, Auckland 0627, New Zealand
[6] Auckland Univ Technol, Inst Biomed Technol, Auckland, New Zealand
[7] Maurice Wilkins Ctr Mol Discovery, Auckland 1010, New Zealand
[8] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518071, Guangdong, Peoples R China
[9] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Shaanxi, Peoples R China
[10] Nanchang Univ, Coll Food Sci & Technol, Nanchang 330031, Jiangxi, Peoples R China
来源：
JOURNAL OF ADVANCED RESEARCH | 2022年 / 37卷
关键词：
Age-induced diseases; Anti-aging; Nicotinamide adenine dinucleotide; Nicotinamide mononucleotide; Supplement; INDUCED COGNITIVE IMPAIRMENT; NAD(+) METABOLISM; ACTIVATION; MITOCHONDRIA; MODULATION; PRECURSORS; MITOPHAGY; MELATONIN; RESPONSES; EXERCISE;
D O I：
10.1016/j.jare.2021.08.003
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Elderly population has been progressively rising in the world, thus the demand for anti aging heath products to assure longevity as well as to ameliorate age-related complications is also on the rise. Among various anti-aging health products, nicotinamide mononucleotide (NMN) has been gaining attentions of the consumers and the scientific community.Aim of review: This article intends to provide an overview on the current knowledge on promises and safety concerns of NMN as an anti-aging health product.Key scientific concepts of review: Nicotinamide adenine dinucleotide (NAD.) levels in the body deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. However, NMN, as the precursor of NAD., can slow down this process by elevating NAD. levels in the body. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN supplementation. One preclinical and one clinical study have been conducted to investigate the safety concerns of NMN administration while a few more human clinical trials are being conducted. As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.(c) 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：267 / 278
页数：12
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