Because of intracellular and extracellular noise perturbations and environment fluctuations, gene regulation is an intrinsically noisy process. In this paper, we present a hybrid genetic regulatory network (GRN) model which is based on the Markov chain. The GRNs are composed of N modes and the network switches from one mode to another according to a Markov chain with known transition probability. Time-delays here are mode-dependent. Based on the Lyapunov stability theory and the linear matrix inequality (LMI) technique, sufficient conditions are given to ensure the stochastic stability of the GRNs with polytopic uncertainties and disturbance attenuation. All the conditions are presented in terms of LMIs which are easily verified via the LMI toolbox. Examples are provided to illustrate the effectiveness of the theoretical results.
机构:
Nanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R ChinaNanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R China
Zhou, Qi
Xu, Shengyuan
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Nanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R ChinaNanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R China
Xu, Shengyuan
Chen, Bing
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Qingdao Univ, Inst Complex Sci, Qingdao 266071, Shandong, Peoples R ChinaNanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R China
Chen, Bing
Li, Hongyi
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Harbin Inst Technol, Space Control & Inertial Technol Res Ctr, Harbin 150001, Peoples R ChinaNanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R China
Li, Hongyi
Chu, Yuming
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Huzhou Teachers Coll, Dept Math, Huzhou 313000, Zhejiang, Peoples R ChinaNanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Jiangsu, Peoples R China