Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome

被引:60
作者
Sidra, Syeda [1 ]
Tariq, Muhammad Haseeb [2 ]
Farrukh, Muhammad Junaid [3 ]
Mohsin, Muhammad [1 ]
机构
[1] Riphah Int Univ, Fac Pharmaceut Sci, Islamabad, Pakistan
[2] Univ Sains Malaysia, Sch Pharmaceut Sci, Dept Clin Pharm, George Town, Malaysia
[3] UCSI Univ, Fac Pharmaceut Sci, Kuala Lumpur, Malaysia
来源
PLOS ONE | 2019年 / 14卷 / 10期
关键词
DEPRESSION; PREVALENCE; IMPACT; ANXIETY; STRESS; PCOS;
D O I
10.1371/journal.pone.0223329
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study aimed to evaluate the clinical manifestations and health risks associated with polycystic ovary syndrome (PCOS) and its impact on quality of life (QOL) in Pakistan. A detailed cross-sectional study was conducted on PCOS among women of reproductive age visiting the gynecology and obstetrics and endocrinology departments at primary and tertiary care hospitals located in Abbottabad, Kohat, and Islamabad. In total, 440 patients meeting the inclusion criteria were included. A checklist was specifically designed to identify symptoms and health risks, including adverse drug reactions, complications, irrational prescription or underprescription, and drug-drug interactions. The Short Form-12 questionnaire was used to evaluate the QOL of patients with PCOS. Data collected were analyzed for descriptive and inferential statistics using chi-square test, analysis of variance, and post hoc analysis. All patients exhibited the cardinal symptoms of PCOS, including obesity (n = 352, 80%), acne (n = 296, 67.3), hirsutism (n = 299, 68%), hyperglycemia (n = 278, 63.2%), and irregular menstruation (n = 316, 71.8%). Ultrasonography confirmed that 268 (61%) patients had multiple cysts of >10 mm in diameter. Patients with untreated PCOS exhibited a high prevalence of health risks including hypertension (n = 87, 19.8%), diabetes (n = 268, 60.9%), sleep apnea (n = 11, 2.5%), infertility (n = 146, 33.2%), increased endometrial thickness (n = 21, 4.8%), miscarriages (n = 68, 15.5%), high cholesterol level (n = 85, 19.3%), and hyperandrogenism (n = 342, 77.7%). Most patients exhibited low QOL scores (n = 374, 85%), with depression being the largest contributor to low QOL. Apart from novel results, this study found an association between depression and low QOL in patients with PCOS, suggesting the need for reviewing the management guidelines and psychological health assessment of women with PCOS.
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页数:17
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