Roles of nuclear factor-κB in postischemic liver

被引:30
作者
Shin, Thomas [1 ]
Kuboki, Satoshi [1 ]
Lentsch, Alex B. [1 ]
机构
[1] Univ Cincinnati, Dept Surg, Cincinnati, OH 45267 USA
关键词
apoptosis; inflammation; ischemia; reperfusion; liver injury; necrosis; nuclear factor-kappa B;
D O I
10.1111/j.1872-034X.2007.00303.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatic ischemia/reperfusion (I/R) results in a chain of events that culminate in liver dysfunction and injury. I/R injury is characterized by early oxidant stress followed by an intense acute inflammatory response that involves the transcription factor nuclear factor (NF)-kappa B. In addition to being a primary regulator of pro-inflammatory gene expression, NF-kappa B may play other roles in the hepatic response to I/R, such as mediating the expression of anti-apoptotic genes, preventing the accumulation of damaging reactive oxygen species, facilitating liver regeneration, and mediating the protective effects of ischemic preconditioning. In the present study, we review the diverse functions of NF-kappa B during hepatic I/R injury.
引用
收藏
页码:429 / 440
页数:12
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