1,3,5-Triazines: A promising scaffold for anticancer drugs development

被引：122

作者：

Cascioferro, Stella ^{[1
]}

Parrino, Barbara ^{[1
]}

Spano, Virginia ^{[1
]}

Carbone, Anna ^{[1
]}

Montalbano, Alessandra ^{[1
]}

Barraja, Paola ^{[1
]}

Diana, Patrizia ^{[1
]}

Cirrincione, Girolamo ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut S, Via Archirafi 32, I-90123 Palermo, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 142卷

关键词：

1,3,5-Triazines; Antitumor activity; Nitrogen heterocycles; Disubstituted 1,3,5-triazines; Trisubstituted 1,3,5-triazines; Heterofused 1,3,5-triazines; CARBONIC-ANHYDRASE INHIBITORS; COMPETITIVE MTOR INHIBITORS; STRUCTURE-BASED DESIGN; BREAST-CANCER CELLS; IN-VITRO EVALUATION; THYMIDINE PHOSPHORYLASE; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; KINASE INHIBITORS; ANTITUMOR EVALUATION;

D O I：

10.1016/j.ejmech.2017.09.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：523 / 549

页数：27

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