Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting

被引:26
|
作者
Rosow, Carl E. [1 ]
Haspel, Kenneth L. [2 ]
Smith, Sarah E. [3 ]
Grecu, Loreta [1 ]
Bittrier, Edward A. [1 ]
机构
[1] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA
[2] Yale Univ, Sch Med, Dept Anesthesiol, Boston, MA USA
[3] Boston Univ, Sch Med, Boston, MA 02118 USA
来源
ANESTHESIA AND ANALGESIA | 2008年 / 106卷 / 05期
关键词
D O I
10.1213/ane.0b013e3181609022
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
BACKGROUND: Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT3 antagonists. METHODS: Two hundred forty-four adults were randomized to receive IV haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design. RESULTS: There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects (78.2% and 76.8%) had complete response. Postoperatively, prolonged QTc occurred in 28.9% and 22.1% (N.S.). CONCLUSIONS: In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol I mg was not significantly different from ondansetron 4 mg.
引用
收藏
页码:1407 / 1409
页数:3
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