Next generation sequencing in gastric or gastroesophageal adenocarcinoma

被引：7

作者：

Ku, Geoffrey Y. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, 1275 York Ave, New York, NY 10021 USA

来源：

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY | 2020年 / 5卷

关键词：

Next generation sequencing (NGS); gastric cancer (GC); targeted therapy; PHASE-III TRIAL; DOUBLE-BLIND; OPEN-LABEL; MICROSATELLITE INSTABILITY; 1ST-LINE THERAPY; PLUS PACLITAXEL; CANCER; CHEMOTHERAPY; CAPECITABINE; OXALIPLATIN;

D O I：

10.21037/tgh.2020.01.09

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Seminal analyses of The Cancer Genome Atlas (TGCA) and Asian Cancer Research Group (ACRG) have provided unprecedented insight into the molecular underpinnings of gastric cancer (GC). At the same time, next generation sequencing (NGS) panels, driven by quantum improvements in DNA sequencing technology and bioinformatics, are now routinely used in standard clinical care and also extensively for research purposes. This review article will discuss the molecular subtypes of GC, the current standard-of-care therapies for GC and the role of NGS in standard care and in research.

引用

页数：9

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