Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes

被引：11
作者：
Zheng, Yanjiang [1 ]
VanDusen, Nathan J. [2 ]
Butler, Catalina E. [2 ]
Ma, Qing [2 ]
King, Justin S. [2 ]
Pu, William T. [2 ,3 ]
机构：
[1] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem, Chengdu, Peoples R China
[2] Boston Childrens Hosp, Dept Cardiol, Boston, MA USA
[3] Harvard Stem Cell Inst, Cambridge, MA USA
来源：
CIRCULATION | 2022年 / 145卷 / 10期
基金：
美国国家卫生研究院;
关键词：
CRISPR-associated protein 9; genome editing; homology-directed dsDNA break repair; myocytes; cardiac;
D O I：
10.1161/CIRCULATIONAHA.120.052383
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：787 / 789
页数：3
相关论文
共 5 条
  • [1] Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo
    Guo, Yuxuan
    VanDusen, Nathan J.
    Zhang, Lina
    Gu, Weiliang
    Sethi, Isha
    Guatimosim, Silvia
    Ma, Qing
    Jardin, Blake D.
    Ai, Yulan
    Zhang, Donghui
    Chen, Biyi
    Guo, Ang
    Yuan, Guo-Cheng
    Song, Long-Sheng
    Pu, William T.
    [J]. CIRCULATION RESEARCH, 2017, 120 (12) : 1874 - +
  • [2] Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes
    Ishizu, Takamaru
    Higo, Shuichiro
    Masumura, Yuki
    Kohama, Yasuaki
    Shiba, Mikio
    Higo, Tomoaki
    Shibamoto, Masato
    Nakagawa, Akito
    Morimoto, Sachio
    Takashima, Seiji
    Hikoso, Shungo
    Sakata, Yasushi
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [3] Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes
    Kohama, Yasuaki
    Higo, Shuichiro
    Masumura, Yuki
    Shiba, Mikio
    Kondo, Takumi
    Ishizu, Takamaru
    Higo, Tomoaki
    Nakamura, Satoki
    Kameda, Satoshi
    Tabata, Tomoka
    Inoue, Hiroyuki
    Motooka, Daisuke
    Okuzaki, Daisuke
    Takashima, Seiji
    Miyagawa, Shigeru
    Sawa, Yoshiki
    Hikoso, Shungo
    Sakata, Yasushi
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [4] Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain
    Nishiyama, Jun
    Mikuni, Takayasu
    Yasuda, Ryohei
    [J]. NEURON, 2017, 96 (04) : 755 - +
  • [5] Advances in genome editing through control of DNA repair pathways
    Yeh, Charles D.
    Richardson, Christopher D.
    Corn, Jacob E.
    [J]. NATURE CELL BIOLOGY, 2019, 21 (12) : 1468 - 1478
1