Light-Mediated Asymmetric Aliphatic C-H Alkylation with Hydrogen Atom Transfer Catalyst and Chiral Phosphoric Acid

被引：65

作者：

Dai, Zhen-Yao ^{[1
]}

Nong, Zhong-Sheng ^{[1
]}

Wang, Pu-Sheng ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ACS CATALYSIS | 2020年 / 10卷 / 08期

关键词：

C-H functionalization; asymmetric photocatalysis; hydrogen atom transfer; enantioselective protonation; chiral phosphoric acid; C(SP(3))-H FUNCTIONALIZATION; DIRECT ARYLATION; BONDS; ACTIVATION; 1,1'-SPIROBIINDANE-7,7'-DIOL; SELECTIVITY;

D O I：

10.1021/acscatal.0c00610

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the presence of tetrabutylammonium decatungstate and chiral Spiro phosphoric acid, a light-mediated asymmetric C-H functionalization of unactivated hydrocarbons with exocyclic enones has been established. A wide range of cycloalkanes, benzylic, and allylic hydrocarbons are tolerated. This protocol proceeds via a hydrogen atom transfer/radical addition/hydrogen abstraction/enantioselective protonation relay process.

引用

页码：4786 / 4790

页数：5

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