Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction

被引：0
作者：
Spasov, A. A. [1 ]
Kucheryavenko, A. F. [1 ]
Khaliullin, F. A. [2 ,3 ]
Gurova, N. A. [1 ]
Sirotenko, V. S. [1 ]
Samorodov, A., V [2 ,3 ]
Gaidukova, K. A. [1 ]
Pavlov, V. N. [2 ,3 ]
机构：
[1] Volgograd State Med Univ, Dept Pharmacol & Bioinformat, Minist Hlth Russian Federat, Volgograd, Russia
[2] Bashkir State Med Univ, Minist Hlth Russian Federat, Dept Pharmaceut Chem, Courses Analyt Chem, Ufa, The Republic Of, Russia
[3] Bashkir State Med Univ, Minist Hlth Russian Federat, Dept Pharmaceut Chem, Course Toxicol Chem, Ufa, The Republic Of, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 172卷 / 03期
关键词：
arterial thrombosis; Angipur; tirofiban; isoproterenol-induced myocardial infarction;
D O I：
10.1007/s10517-022-05383-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, Angipur administered intravenously was 1.2 times less effective, in terms of ED50, than the well-known inhibitor of GPIIb/IIIa platelet receptors tirofiban. However, under conditions of non-coronary myocardial infarction, Angipur significantly prolonged the time of thrombus formation and exhibited 1.4-fold higher activity than the reference drug tirofiban.
引用
收藏
页码：314 / 317
页数：4
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