Effectiveness of allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia

被引：11

作者：

Appelbaum, Frederick R. ^{[1
,2
]}

机构：

[1] Univ Washington, 1100 Fairview Ave, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave, Seattle, WA 98109 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2021年 / 34卷 / 04期

关键词：

Allogeneic hematopoietic cell transplantation; Acute myeloid leukemia; CYCLOPHOSPHAMIDE;

D O I：

10.1016/j.beha.2021.101320

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Outcomes with conventional chemotherapy for older patients with acute myeloid leukemia (AML) remain disappointing, with few cures. For younger patients with AML, allogeneic hematopoietic cell transplantation (HCT) offers the best chance for cure, but this strategy is seldomly used for older patients. With recently improved methodologies, transplantation has become increasingly safe, suggesting that its use in older patients be reconsidered. This report will address four issues: the current frequency of transplantation for AML according to patient age; the impact of patient age on transplant outcomes; the comparative outcomes of transplantation versus chemotherapy for older patients with AML; and possible methods to improve the outcome of allogeneic HCT in older patients with AML.

引用

页数：6

共 21 条

[1] Hypomethylating agents as maintenance therapy following allogeneic hematopoietic cell transplantation for myeloid malignancies [J].

Appelbaum, Frederick R. .

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2021, 34 (01)

[2] Reduced Intensity Conditioned Sibling Transplantation Versus No Transplant in Intermediate or High Risk Acute Myeloid Leukemia: A Prospective Multi-Center Study in Patients 50-70 Years in First Complete Remission and with at Least One Potential Sibling Donor (ClinTrialGov 00342316) [J].

Brune, Mats ;

Kiss, Thomas L. ;

Wallhult, Elisabeth ;

Anderson, Harald ;

Delage, Robert ;

Finke, Juergen ;

Hebert, Josee ;

Hoglund, Martin ;

Kaare, Ain ;

Lazarevic, Vladimir ;

Nicklasson, Malin ;

Remes, Kari ;

Ritchie, David ;

Sabloff, Mitchell ;

Spearing, Ruth ;

Spyridonidis, Alexandros ;

Szer, Jeffrey ;

Ljungman, Per .

BLOOD, 2018, 132

[3] Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia [J].

DiNardo, C. D. ;

Jonas, B. A. ;

Pullarkat, V. ;

Thirman, M. J. ;

Garcia, J. S. ;

Wei, A. H. ;

Konopleva, M. ;

Doehner, H. ;

Letai, A. ;

Fenaux, P. ;

Koller, E. ;

Havelange, V. ;

Leber, B. ;

Esteve, J. ;

Wang, J. ;

Pejsa, V. ;

Hajek, R. ;

Porkka, K. ;

Illes, A. ;

Lavie, D. ;

Lemoli, R. M. ;

Yamamoto, K. ;

Yoon, S. -S. ;

Jang, J. -H. ;

Yeh, S. -P. ;

Turgut, M. ;

Hong, W. -J. ;

Zhou, Y. ;

Potluri, J. ;

Pratz, K. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (07) :617-629

[4] Comparison of Reduced-Intensity Hematopoietic Cell Transplantation with Chemotherapy in Patients Age 60-70 Years with Acute Myelogenous Leukemia in First Remission [J].

Farag, Sherif S. ;

Maharry, Kati ;

Zhang, Mei-Jie ;

Perez, Waleska S. ;

George, Stephen L. ;

Mrozek, Krzysztof ;

DiPersio, John ;

Bunjes, Donald W. ;

Marcucci, Guido ;

Baer, Maria R. ;

Cairo, Mitchell ;

Copelan, Edward ;

Cutler, Corey S. ;

Isola, Luis ;

Lazarus, Hillard M. ;

Litzow, Mark R. ;

Marks, David I. ;

Ringden, Olle ;

Rizzieri, David A. ;

Soiffer, Robert ;

Larson, Richard A. ;

Tallman, Martin S. ;

Bloomfield, Clara D. ;

Weisdorf, Daniel J. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (12) :1796-1803

[5] Effect of rhG-CSF Combined With Decitabine Prophylaxis on Relapse of Patients With High-Risk MRD-Negative AML After HSCT: An Open-Label, Multicenter, Randomized Controlled Trial [J].

Gao, Lei ;

Zhang, Yanqi ;

Wang, Sanbin ;

Kong, Peiyan ;

Su, Yi ;

Hu, Jiong ;

Jiang, Ming ;

Bai, Hai ;

Lang, Tao ;

Wang, Jishi ;

Liu, Li ;

Yang, Tonghua ;

Huang, Xiaobing ;

Liu, Fang ;

Lou, Shifeng ;

Liu, Yao ;

Zhang, Cheng ;

Liu, Hong ;

Gao, Li ;

Liu, Jia ;

Zhu, Lidan ;

Wen, Qin ;

Chen, Ting ;

Wang, Ping ;

Rao, Jun ;

Mao, Min ;

Wang, Cunbang ;

Duan, Xianlin ;

Luo, Le ;

Peng, Xiangui ;

Cassady, Kaniel ;

Zhong, Jiang F. ;

Zhang, Xi .

JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (36) :4249-+

[6] Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation. [J].

Gooley, Ted A. ;

Chien, Jason W. ;

Pergam, Steven A. ;

Hingorani, Sangeeta ;

Sorror, Mohamed L. ;

Boeckh, Michael ;

Martin, Paul J. ;

Sandmaier, Brenda M. ;

Marr, Kieren A. ;

Appelbaum, Frederick R. ;

Storb, Rainer ;

McDonald, George B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (22) :2091-2101

[7] Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70 [J].

Imus, Philip H. ;

Tsai, Hua-Ling ;

Luznik, Leo ;

Fuchs, Ephraim J. ;

Huff, Carol Ann ;

Gladstone, Douglas E. ;

Lowery, Patrick ;

Ambinder, Richard F. ;

Borrello, Ivan M. ;

Swinnen, Lode J. ;

Wagner-Johnston, Nina ;

Gocke, Christian B. ;

Ali, Syed Abbas ;

Bolanos-Meade, F. Javier ;

Varadhan, Ravi ;

Jones, Richard J. .

BLOOD ADVANCES, 2019, 3 (17) :2608-2616

[8] Acute myeloid leukemia in the real world: why population-based registries are needed [J].

Juliusson, Gunnar ;

Lazarevic, Vladimir ;

Horstedt, Ann-Sofi ;

Hagberg, Oskar ;

Hoglund, Martin .

BLOOD, 2012, 119 (17) :3890-3899

[9] Phase I study of 131I-anti-CD45 antibody plus cyclophosphamide and total body irradiation for advanced acute leukemia and myelodysplastic syndrome [J].

Matthews, DC ;

Appelbaum, FR ;

Eary, JF ;

Fisher, DR ;

Durack, LD ;

Hui, TE ;

Martin, PJ ;

Mitchell, D ;

Press, OW ;

Storb, R ;

Bernstein, ID .

BLOOD, 1999, 94 (04) :1237-1247

[10] Survival, Nonrelapse Mortality, and Relapse-Related Mortality After Allogeneic Hematopoietic Cell Transplantation: Comparing 2003-2007 Versus 2013-2017 Cohorts [J].

McDonald, George B. ;

Sandmaier, Brenda M. ;

Mielcarek, Marco ;

Sorror, Mohamed ;

Pergam, Steven A. ;

Cheng, Guang-Shing ;

Hingorani, Sangeeta ;

Boeckh, Michael ;

Flowers, Mary D. ;

Lee, Stephanie J. ;

Appelbaum, Frederick R. ;

Storb, Rainer ;

Martin, Paul J. ;

Deeg, H. Joachim ;

Schoch, Gary ;

Gooley, Ted A. .

ANNALS OF INTERNAL MEDICINE, 2020, 172 (04) :229-+

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