A review of the mechanisms and biomarkers of allergen immunotherapy

被引：1
作者：
Wilk, Mateusz [1 ]
Ptak, Jakub [1 ]
Tomczyk, Bartosz [1 ]
Kruczkowska, Adrianna [1 ]
Kanturski, Andrzej [1 ]
Gomulka, Krzysztof [2 ]
机构：
[1] Wroclaw Med Univ, Student Res Grp Adult Allergol, Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Internal Med Pneumol & Allergol, Wroclaw, Poland
来源：
MEDICAL STUDIES-STUDIA MEDYCZNE | 2021年 / 37卷 / 04期
关键词：
immunotherapy; allergy; desensitization; T-CELL FUNCTION; ORAL IMMUNOTHERAPY; CLINICAL-EFFICACY; FOOD ALLERGY; PEANUT; IGE; CHALLENGES; INCREASES; CORRELATE; PROMOTES;
D O I：
10.5114/ms.2021.112388
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Allergen immunotherapy has been shown to be successful in numerous clinical trials, even leading to complete relief of allergic symptoms. However, the molecular mechanisms behind these outcomes remain unclear, substantially hindering introduction of more efficient and safer protocols. The current gold standard of assessing the effects of allergen immunotherapy is a challenge test, which might be both unpleasant and dangerous for patients. Better understanding of the molecular background of allergen immunotherapy would allow us to substitute challenge tests with biomarkers. These might also be used to predict a patient's response to the treatment. Here, we review current knowledge regarding immune responses to allergen immunotherapy and its potential biomarkers.
引用
收藏
页码：322 / 330
页数：9
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