Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides

被引：29

作者：

Raffa, Demetrio ^{[1
]}

Maggio, Benedetta ^{[1
]}

Plescia, Fabiana ^{[1
]}

Cascioferro, Stella ^{[1
]}

Plescia, Salvatore ^{[1
]}

Raimondi, Maria Valeria ^{[1
]}

Daidone, Giuseppe ^{[1
]}

Tolomeo, Manlio ^{[2
,3
]}

Grimaudo, Stefania ^{[2
,3
]}

Di Cristina, Antonietta ^{[2
,3
]}

Pipitone, Rosaria Maria ^{[2
,3
]}

Bai, Ruoli ^{[4
]}

Hamel, Ernest ^{[4
]}

机构：

[1] Dipartimento Sci & Tecnol Mol & Biomol, I-90123 Palermo, Italy

[2] Univ Palermo, Ctr Interdipartimentale Ric Oncol Clin, Palermo, Italy

[3] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Palermo, Italy

[4] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 07期

关键词：

2-{[2E]-3-phenylprop-2-enoylamino}benzamides; Antimitotic agents; Cytotoxic activity; ANTIMITOTIC AGENTS; TUBULIN; DERIVATIVES; CELLS;

D O I：

10.1016/j.ejmech.2011.03.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several new 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides 12a-s and 17t-v were synthesized by stirring in pyridine the (E)-3-(2-R1-3-R2-4-R3-phenyl)acrylic acid chlorides 11c-k and 11t-v with the appropriate anthranilamide derivatives 10a-c or the 5-iodoanthranilic acid 13. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). COMPARE analysis, effects on tubulin polymerization in cells and with purified tubulin, and effects on cell cycle distribution for 17t, the most active of the series, indicate that these new antiproliferative compounds act as antitubulin agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：2786 / 2796

页数：11

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